WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H462238
CAS#: 1263774-57-7
Description: JAK3-IN-7 is a potent and selective JAK3 inhibitor.
Hodoodo Cat#: H462238
Name: JAK3-IN-7
CAS#: 1263774-57-7
Chemical Formula: C17H20N6O
Exact Mass: 324.17
Molecular Weight: 324.388
Elemental Analysis: C, 62.95; H, 6.21; N, 25.91; O, 4.93
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Synonym: JAK3-IN-7; JAK3IN7; JAK3 IN 7
IUPAC/Chemical Name: 3-(3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.5]nonan-1-yl)-3-oxopropanenitrile
InChi Key: YAGUGWDMCPHBFF-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H20N6O/c1-12-9-23(14(24)3-6-18)17(12)5-2-8-22(10-17)16-13-4-7-19-15(13)20-11-21-16/h4,7,11-12H,2-3,5,8-10H2,1H3,(H,19,20,21)
SMILES Code: CC(CN1C(CC#N)=O)C1(CCC2)CN2C3=C(C=CN4)C4=NC=N3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 324.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: NOJI, Satoru, et al. NITROGEN-CONTAINING SPIRO-RING COMPOUND AND MEDICINAL USE OF SAME. WO2011013785A1.