WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H534976
CAS#: 77650-95-4
Description: Proterguride is a bioactive chemical.
Hodoodo Cat#: H534976
Name: Proterguride
CAS#: 77650-95-4
Chemical Formula: C22H32N4O
Exact Mass: 368.26
Molecular Weight: 368.525
Elemental Analysis: C, 71.70; H, 8.75; N, 15.20; O, 4.34
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Proterguride
IUPAC/Chemical Name: Urea, N,N-diethyl-N'-((8-alpha)-6-propylergolin-8-yl)-
InChi Key: FCRJELOYDVBTGW-ILZDJORESA-N
InChi Code: InChI=1S/C22H32N4O/c1-4-10-26-14-16(24-22(27)25(5-2)6-3)12-18-17-8-7-9-19-21(17)15(13-23-19)11-20(18)26/h7-9,13,16,18,20,23H,4-6,10-12,14H2,1-3H3,(H,24,27)/t16-,18+,20+/m0/s1
SMILES Code: O=C(N[C@@H](C[C@@]12[H])CN(CCC)[C@]1([H])CC3=CNC4=C3C2=CC=C4)N(CC)CC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 368.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Schurad B, Horowski R, Jähnichen S, Görnemann T, Tack J, Pertz HH. Proterguride, a highly potent dopamine receptor agonist promising for transdermal administration in Parkinson's disease: interactions with alpha(1)-, 5-HT(2)- and H(1)-receptors. Life Sci. 2006 Apr 11;78(20):2358-64. doi: 10.1016/j.lfs.2005.09.046. Epub 2005 Nov 28. PMID: 16310806.
2: Schurad B, Tack J, Lipp R. Evaluation of the transdermal permeation behavior of Proterguride from drug in adhesive matrix patches through hairless mouse skin. Drug Dev Ind Pharm. 2005 Jul;31(6):505-13. doi: 10.1080/03639040500215842. PMID: 16109623.
3: Krause W, Düsterberg B, Jakobs U, Hoyer GA. Biotransformation of proterguride in the perfused rat liver. Drug Metab Dispos. 1993 Mar-Apr;21(2):203-8. PMID: 8097686.
4: Brücke T, Bankiewicz K, Harvey-White J, Kopin I. The partial dopamine receptor agonist terguride in the MPTP-induced hemiparkinsonian monkey model. Eur J Pharmacol. 1988 Apr 13;148(3):445-8. doi: 10.1016/0014-2999(88)90125-2. PMID: 3260191.
5: Krause W, Hümpel M. Pharmacokinetics of proterguride in rat and cynomolgus monkey. Xenobiotica. 1988 Jan;18(1):41-8. doi: 10.3109/00498258809055135. PMID: 3354231.
