WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H574504
CAS#: 121324-31-0
Description: POV-PC is an oxLDL species that confers CD36 scavenger receptor binding affinity more potently than any hydroperoxy PC species. Treatment of cultured endothelial cells with POV-PC stimulates monocyte binding, stimulates intracellular cAMP production, and strongly inhibits the LPS-induced binding of neutrophils.
Hodoodo Cat#: H574504
Name: POV-PC
CAS#: 121324-31-0
Chemical Formula: C29H57NO9P
Exact Mass: 594.38
Molecular Weight: 594.746
Elemental Analysis: C, 58.57; H, 9.66; N, 2.36; O, 24.21; P, 5.21
Synonym: POV-PC
IUPAC/Chemical Name: 2-((hydroxy((R)-2-((5-oxopentanoyl)oxy)-3-(palmitoyloxy)propoxy)phosphoryl)oxy)-N,N,N-trimethylethan-1-aminium
InChi Key: RKIDALSACBQVTN-HHHXNRCGSA-N
InChi Code: InChI=1S/C29H56NO9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-20-28(32)36-25-27(39-29(33)21-18-19-23-31)26-38-40(34,35)37-24-22-30(2,3)4/h23,27H,5-22,24-26H2,1-4H3/t27-/m1/s1
SMILES Code: CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCC[N](C)(C)C)OC(=O)CCCC=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Side Chain Carbon Sum: 21:0
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 594.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Podrez, E.A., Febbraio, M., Sheibani, N., et al. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J. Clin. Invest. 105(8), 1095-1108 (2000).
2. Podrez, E.A., Poliakov, E., Shen, Z., et al. A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions. J. Biol. Chem. 277 (41), 38517-38523 (2002).
3. Podrez, E.A., Poliakov, E., Shen, Z., et al. Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36. The Journal of Biological Chemisty 277(41), 38503-38516 (2002).
4. Leitinger, N., Tyner, T.R., Oslund, L., et al. Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils. Proceedings of the National Academy of Sciences of the United States of America 96(21), 12010-12015 (1999).