WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H535120
CAS#: 926914-55-8
Description: Pyflubumide is a bioactive chemical.
Hodoodo Cat#: H535120
Name: Pyflubumide
CAS#: 926914-55-8
Chemical Formula: C25H33F6N3O3
Exact Mass: 537.24
Molecular Weight: 537.547
Elemental Analysis: C, 55.86; H, 6.19; F, 21.21; N, 7.82; O, 8.93
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Synonym: Pyflubumide
IUPAC/Chemical Name: 3-Isobutyl-N-isobutyryl-1,3,5-trimethyl-4-(2,2,2-trifluoro-1-methoxy-1-(trifluoromethyl)ethyl)pyrazole-4-carboxanilide
InChi Key: DSLUQJGWMNUQOY-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H33F6N3O3/c1-15(2)14-21(6)22(17(5)33(7)32-21,23(37-8,24(26,27)28)25(29,30)31)20(36)34(19(35)16(3)4)18-12-10-9-11-13-18/h9-13,15-16H,14H2,1-8H3
SMILES Code: O=C(C1(C(C(F)(F)F)(OC)C(F)(F)F)=C(C)N(C)N=C1(CC(C)C)C)N(C(C(C)C)=O)C2=CC=CC=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 537.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Furuya T, Machiya K, Fujioka S, Nakano M, Inagaki K. Development of a novel acaricide, pyflubumide. J Pestic Sci. 2017 Aug 20;42(3):132-136. doi: 10.1584/jpestics.J17-02. PMID: 30363851; PMCID: PMC6183382.
2: Li QB, Liao M, Liu Q, Feng T, Xu ZY, Rui CH, Liu SZ. Design, Synthesis, and Biological Activities of Novel 1,3,5-Trimethylpyrazole-Containing Malonamide Derivatives. Molecules. 2019 Feb 3;24(3):562. doi: 10.3390/molecules24030562. PMID: 30717498; PMCID: PMC6385117.
3: Sugimoto N, Takahashi A, Ihara R, Itoh Y, Jouraku A, Van Leeuwen T, Osakabe M. QTL mapping using microsatellite linkage reveals target-site mutations associated with high levels of resistance against three mitochondrial complex II inhibitors in Tetranychus urticae. Insect Biochem Mol Biol. 2020 May 19;123:103410. doi: 10.1016/j.ibmb.2020.103410. Epub ahead of print. PMID: 32442626.
4: Van Leeuwen T, Tirry L, Yamamoto A, Nauen R, Dermauw W. The economic importance of acaricides in the control of phytophagous mites and an update on recent acaricide mode of action research. Pestic Biochem Physiol. 2015 Jun;121:12-21. doi: 10.1016/j.pestbp.2014.12.009. Epub 2014 Dec 12. PMID: 26047107.