WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H462526
CAS#: 925069-34-7
Description: PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor. It can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.
Hodoodo Cat#: H462526
Name: PI-273
CAS#: 925069-34-7
Chemical Formula: C16H16ClN3O2S2
Exact Mass: 381.04
Molecular Weight: 381.893
Elemental Analysis: C, 50.32; H, 4.22; Cl, 9.28; N, 11.00; O, 8.38; S, 16.79
Synonym: PI-273; PI273; PI 273
IUPAC/Chemical Name: 2-(3-(4-chlorobenzoyl)thioureido)-4-ethyl-5-methylthiophene-3-carboxamide
InChi Key: MIERMBQDBLFAFW-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H16ClN3O2S2/c1-3-11-8(2)24-15(12(11)13(18)21)20-16(23)19-14(22)9-4-6-10(17)7-5-9/h4-7H,3H2,1-2H3,(H2,18,21)(H2,19,20,22,23)
SMILES Code: O=C(C1=C(NC(NC(C2=CC=C(Cl)C=C2)=O)=S)SC(C)=C1CC)N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 381.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Li J, Gao Z, Zhao D, et al. PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells. Cancer Res. 2017;77(22):6253-6266. doi:10.1158/0008-5472.CAN-17-0484