WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H462553
CAS#: 1429624-84-9
Description: PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor. It also inhibits PI3Kδ and PI3Kγ.
Hodoodo Cat#: H462553
Name: PI4KIIIbeta-IN-9
CAS#: 1429624-84-9
Chemical Formula: C23H25N3O5S2
Exact Mass: 487.12
Molecular Weight: 487.589
Elemental Analysis: C, 56.66; H, 5.17; N, 8.62; O, 16.41; S, 13.15
This product is not in stock, which may be available by custom synthesis.
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Synonym: PI4KIIIbeta-IN-9; PI4KIIIbeta IN 9; PI4KIIIbeta IN-9; PI4KIIIbeta IN-9
IUPAC/Chemical Name: N-(5-(3-(N-(4-hydroxyphenyl)sulfamoyl)-4-methoxyphenyl)-4-methylthiazol-2-yl)cyclopentanecarboxamide
InChi Key: KAXNDTMKFONXJM-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H25N3O5S2/c1-14-21(32-23(24-14)25-22(28)15-5-3-4-6-15)16-7-12-19(31-2)20(13-16)33(29,30)26-17-8-10-18(27)11-9-17/h7-13,15,26-27H,3-6H2,1-2H3,(H,24,25,28)
SMILES Code: CC(N=C1NC(C2CCCC2)=O)=C(S1)C3=CC=C(C(S(=O)(NC4=CC=C(O)C=C4)=O)=C3)OC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 487.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Rutaganira FU, Fowler ML, McPhail JA, et al. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. J Med Chem. 2016;59(5):1830-1839. doi:10.1021/acs.jmedchem.5b01311