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Polysorbate 40
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H462696

CAS#: 9005-66-7

Description: Polysorbate 40 is a class of emulsifiers used in some pharmaceuticals and food preparation. It is often used in cosmetics to solubilize essential oils into water-based products. Polysorbates are oily liquids derived from ethoxylated sorbitan esterified with fatty acids.

Chemical Structure

Polysorbate 40

CAS# 9005-66-7

Instruction

Theoretical Analysis

Hodoodo Cat#: H462696
Name: Polysorbate 40
CAS#: 9005-66-7
Chemical Formula: C26H50O10
Exact Mass: 522.34
Molecular Weight: 522.676
Elemental Analysis: C, 59.75; H, 9.64; O, 30.61

Price and Availability

Size	Price	Availability
10mg	USD -2	2 Weeks
25mg	USD -2	2 Weeks
50mg	USD -2	2 Weeks
100mg	USD -2	2 Weeks
200mg	USD -2	2 Weeks
500mg	USD -2	2 Weeks
1g	USD -2	2 Weeks
5g	USD -2	2 Weeks
2g	USD 580	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Tween 40; Polysorbate 40;

IUPAC/Chemical Name: 2-((R)-2-((2R,3R,4R)-3,4-bis(2-hydroxyethoxy)tetrahydrofuran-2-yl)-2-(2-hydroxyethoxy)ethoxy)ethyl dodecanoate

InChi Key: HMFKFHLTUCJZJO-OQUNMALSSA-N

InChi Code: InChI=1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3/t22-,23-,25-,26-/m1/s1

SMILES Code: CCCCCCCCCCCC(OCCOC[C@H]([C@H]1OC[C@H]([C@H]1OCCO)OCCO)OCCO)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 522.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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7: Poša M, Pilipović A, Bećarević M, Farkaš Z. pKa values of hyodeoxycholic and cholic acids in the binary mixed micelles sodium-hyodeoxycholate-Tween 40 and sodium-cholate-Tween 40: Thermodynamic stability of the micelle and the cooperative hydrogen bond formation with the steroid skeleton. Steroids. 2017 Jan;117:62-70. doi: 10.1016/j.steroids.2016.09.012. Epub 2016 Sep 17. PMID: 27651024.

8: Liu CY, Tseng WL. Colorimetric assay for cyanide and cyanogenic glycoside using polysorbate 40-stabilized gold nanoparticles. Chem Commun (Camb). 2011 Mar 7;47(9):2550-2. doi: 10.1039/c0cc04591h. Epub 2011 Jan 10. PMID: 21218238.

9: O'Sullivan SM, Woods JA, O'Brien NM. Use of Tween 40 and Tween 80 to deliver a mixture of phytochemicals to human colonic adenocarcinoma cell (CaCo-2) monolayers. Br J Nutr. 2004 May;91(5):757-64. doi: 10.1079/BJN20041094. PMID: 15137928.

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12: Kim J, Hirasawa T, Saito M, Furusawa C, Shimizu H. Investigation of phosphorylation status of OdhI protein during penicillin- and Tween 40-triggered glutamate overproduction by Corynebacterium glutamicum. Appl Microbiol Biotechnol. 2011 Jul;91(1):143-51. doi: 10.1007/s00253-011-3275-6. Epub 2011 Apr 19. PMID: 21503757.

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15: Ciok-Pater E, Wróblewska J, Białucha A, Gospodarek E. Ocena przydatności testu API ZYM i podłoza RPMI wzbogaconego w Tween 40 do wykrywania lipolitycznych enzymów Candida sp [Evaluation of the API ZYM system and RPMI agar plates supplemented with Tween 40 for detection of lipolytic enzymes of Candida spp]. Med Dosw Mikrobiol. 2011;63(3):263-6. Polish. PMID: 22184921.

16: Podlogar F, Bester Rogac M, Gasperlin M. The effect of internal structure of selected water-Tween 40-Imwitor 308-IPM microemulsions on ketoprofene release. Int J Pharm. 2005 Sep 30;302(1-2):68-77. doi: 10.1016/j.ijpharm.2005.06.023. PMID: 16099611.

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19: Saberi AH, Zeeb B, Weiss J, McClements DJ. Tuneable stability of nanoemulsions fabricated using spontaneous emulsification by biopolymer electrostatic deposition. J Colloid Interface Sci. 2015 Oct 1;455:172-8. doi: 10.1016/j.jcis.2015.05.037. Epub 2015 May 29. PMID: 26070187.

20: Sharma H, Sharma SN, Kumar U, Singh VN, Mehta BR, Singh G, Shivaprasad SM, Kakkar R. Formation of water-soluble and biocompatible TOPO-capped CdSe quantum dots with efficient photoluminescence. J Mater Sci Mater Med. 2009 Dec;20 Suppl 1:S123-30. doi: 10.1007/s10856-008-3494-2. Epub 2008 Jun 21. PMID: 18568389.