WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H574840
CAS#: 105812-81-5
Description: Paroxol is an intermediate in the synthesis of Paroxetine -- a selective serotonin reuptake inhibitor.
Hodoodo Cat#: H574840
Name: Paroxol
CAS#: 105812-81-5
Chemical Formula: C13H18FNO
Exact Mass: 223.14
Molecular Weight: 223.290
Elemental Analysis: C, 69.93; H, 8.13; F, 8.51; N, 6.27; O, 7.17
Synonym: Paroxol
IUPAC/Chemical Name: (4R,3S)-4-(4-Fluorophenyl)-1-methyl-3-piperidinemethanol
InChi Key: CXRHUYYZISIIMT-AAEUAGOBSA-N
InChi Code: InChI=1S/C13H18FNO/c1-15-7-6-13(11(8-15)9-16)10-2-4-12(14)5-3-10/h2-5,11,13,16H,6-9H2,1H3/t11-,13-/m0/s1
SMILES Code: OC[C@@H]1CN(C)CC[C@H]1C2=CC=C(F)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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In vitro activity: | |
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The following data is based on the product molecular weight 223.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Bao Z, Su B, Xing H, Yang Y, Ren Q. Enantioseparation of racemic paroxol on an amylose-based chiral stationary phase by supercritical fluid chromatography. J Sep Sci. 2010 Oct;33(20):3256-62. doi: 10.1002/jssc.201000422. PMID: 20836081.