WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H574843
CAS#: 169528-11-4
Description: PD-149163 is a selective, brain penetrating Neurotensin NTR1 receptor agonist. Neurotensin agonists block the pre-pulse inhibition deficits produced by a 5-HT2A and an α1 agonist. As a result, PD-149163 shows pro-cognitive, anti-psychotic and anxiolytic effects.
Hodoodo Cat#: H574843
Name: PD-149163
CAS#: 169528-11-4
Chemical Formula: C42H71N9O6
Exact Mass: 797.55
Molecular Weight: 798.090
Elemental Analysis: C, 63.21; H, 8.97; N, 15.80; O, 12.03
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Synonym: PD-149163; PD149163; PD 149163; PF-01472472
IUPAC/Chemical Name: N2-[(2S)-2,6-Diaminohexyl]-L-lysyl-L-prolyl-L-tryptophyl-3-methyl-L-valyl-L-leucine Ethyl Ester
InChi Key: LVROVYGTQUFAMB-IDESOYSGSA-N
InChi Code: InChI=1S/C42H71N9O6/c1-7-57-41(56)34(23-27(2)3)49-39(54)36(42(4,5)6)50-37(52)33(24-28-25-46-31-17-9-8-16-30(28)31)48-38(53)35-19-14-22-51(35)40(55)32(18-11-13-21-44)47-26-29(45)15-10-12-20-43/h8-9,16-17,25,27,29,32-36,46-47H,7,10-15,18-24,26,43-45H2,1-6H3,(H,48,53)(H,49,54)(H,50,52)/t29-,32-,33-,34-,35-,36+/m0/s1
SMILES Code: CC(C)C[C@@H](C(OCC)=O)NC([C@H](C(C)(C)C)NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@H]3N(C([C@H](CCCCN)NC[C@@H](N)CCCCN)=O)CCC3)=O)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 798.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Grimond-Billa SK, Norman C, G W B, Cassaday HJ. Selectively increased trace conditioning under the neurotensin agonist PD 149163 in an aversive procedure in which SR 142948A was without intrinsic effect. J Psychopharmacol. 2008 May;22(3):290-9. doi: 10.1177/0269881106081528. PMID: 18308776.
2. Vadnie CA, Ayers-Ringler J, Oliveros A, Abulseoud OA, Choi S, Hitschfeld MJ, Choi DS. Antipsychotic-like effects of a neurotensin receptor type 1 agonist. Behav Brain Res. 2016 May 15;305:8-17. doi: 10.1016/j.bbr.2016.02.019. Epub 2016 Feb 22. PMID: 26909848; PMCID: PMC4808331.
3. Steele FF 3rd, Whitehouse SC, Aday JS, Prus AJ. Neurotensin NTS1 and NTS2 receptor agonists produce anxiolytic-like effects in the 22-kHz ultrasonic vocalization model in rats. Brain Res. 2017 Mar 1;1658:31-35. doi: 10.1016/j.brainres.2017.01.012. Epub 2017 Jan 12. PMID: 28089664.
