PNU-96415E
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H574848

CAS#: 170856-41-4

Description: PNU-96415E is an antipsychotic agent that displays high affinity for dopamine D4 and serotonergic 5-HT2A receptors. It inhibits exploratory locomotor activity and antagonizes d-amphetamine-induced locomotor stimulation in rats.

Chemical Structure

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PNU-96415E
CAS# 170856-41-4
Instruction

Theoretical Analysis

Hodoodo Cat#: H574848
Name: PNU-96415E
CAS#: 170856-41-4
Chemical Formula: C21H27Cl2FN2O
Exact Mass: 412.15
Molecular Weight: 413.358
Elemental Analysis: C, 61.02; H, 6.58; Cl, 17.15; F, 4.60; N, 6.78; O, 3.87

Price and Availability

Size Price Availability Quantity
10mg USD 335 2 Weeks
50mg USD 1065 2 Weeks
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Synonym: PNU-96415E; PNU 96415E; PNU96415E

IUPAC/Chemical Name: 1-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluorophenyl)piperazine dihydrochloride

InChi Key: OGMGYKPECFQXJJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H25FN2O.2ClH/c22-18-5-7-19(8-6-18)24-14-12-23(13-15-24)11-9-21-20-4-2-1-3-17(20)10-16-25-21;;/h1-8,21H,9-16H2;2*1H

SMILES Code: FC1=CC=C(N2CCN(CCC3C4=CC=CC=C4CCO3)CC2)C=C1.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 413.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Tang et al (1997) PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties. J.Pharmacol.Exp.Ther. 281 440 PMID: 9103528

2. Goudie et al (1998) Discriminative stimulus properties of the atypical neuroleptic cloz. in rats: tests with subtype selective receptor ligands. Behav.Pharmacol. 9 699 PMID: 9890260