PS77
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H574849

CAS#: 1450888-35-3

Description: PS77 is a Pkh inhibitor directed to the PIF-pocket with increased selectivity for C. albicans Pkh2.

Chemical Structure

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PS77
CAS# 1450888-35-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H574849
Name: PS77
CAS#: 1450888-35-3
Chemical Formula: C23H18Cl2O3S2
Exact Mass: 476.01
Molecular Weight: 477.410
Elemental Analysis: C, 57.86; H, 3.80; Cl, 14.85; O, 10.05; S, 13.43

Price and Availability

Size Price Availability Quantity
5mg USD 295 2 Weeks
10mg USD 480 2 Weeks
25mg USD 850 2 Weeks
50mg USD 1280 2 Weeks
100mg USD 2000 2 Weeks
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Synonym: PS77; PS 77; PS-77

IUPAC/Chemical Name: {3-(4-Chloro-phenyl)-1-[2-(4-chloro-phenylsulfanyl)-phenyl]-3-oxo-propylsulfanyl}-acetic acid

InChi Key: VAULNRMHUJFUGY-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H18Cl2O3S2/c24-16-7-5-15(6-8-16)20(26)13-22(29-14-23(27)28)19-3-1-2-4-21(19)30-18-11-9-17(25)10-12-18/h1-12,22H,13-14H2,(H,27,28)

SMILES Code: O=C(O)CSC(C1=CC=CC=C1SC2=CC=C(Cl)C=C2)CC(C3=CC=C(Cl)C=C3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 477.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Pastor-Flores D, Schulze JO, Bahí A, Giacometti R, Ferrer-Dalmau J, Passeron S, Engel M, Süss E, Casamayor A, Biondi RM. PIF-pocket as a target for C. albicans Pkh selective inhibitors. ACS Chem Biol. 2013 Oct 18;8(10):2283-92. doi: 10.1021/cb400452z. Epub 2013 Aug 22. PMID: 23911092.

2. Li J, Wang J, Hou W, Jing Z, Tian C, Han Y, Liao J, Dong MQ, Xu X. Phosphorylation of Ataxin-10 by polo-like kinase 1 is required for cytokinesis. Cell Cycle. 2011 Sep 1;10(17):2946-58. doi: 10.4161/cc.10.17.15922. Epub 2011 Sep 1. PMID: 21857149.