WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H463118
CAS#: 119-13-1
Description: D-δ-Tocopherol is a biologically active form of vitamin E, a lipid-soluble antioxidant that protects cellular membranes from oxidative damage. It reduces cumene hydroperoxide-induced lipid peroxidation in hepatocytes when used at a concentration of 20 µM but induces lipid peroxidation in hepatic microsomes at 100 µM. D-δ-Tocopherol decreases capillary formation of HMEC-1 blood endothelial cells. It also decreases the expression of VCAM in, and the invasiveness of, HMEC-1 cells. D-δ-Tocopherol reduces estrogen-induced increases in the expression of the estrogen-responsive genes encoding TFF/pS2, cathepsin D, PGR, CITED1, and SERPINA1 and the levels of 8-hydroxy-2’-deoxyguanosine (8-oxo-dG) and nitrotyrosine in MCF-7 breast cancer cells. Dietary administration of D-δ-Tocopherol reduces tumor growth in an estrogen-supplemented MCF-7 mouse xenograft model.
Hodoodo Cat#: H463118
Name: D-δ-Tocopherol
CAS#: 119-13-1
Chemical Formula: C27H46O2
Exact Mass: 402.35
Molecular Weight: 402.663
Elemental Analysis: C, 80.54; H, 11.52; O, 7.95
Synonym: D-δ-Tocopherol; Dδ-Tocopherol; D δ-Tocopherol; D-δTocopherol; D-δ Tocopherol; DδTocopherol; D δ Tocopherol; (+)-δ-Tocopherol;
IUPAC/Chemical Name: (S)-2,8-dimethyl-2-((4S,8S)-4,8,12-trimethyltridecyl)chroman-6-ol
InChi Key: GZIFEOYASATJEH-BERHBOFZSA-N
InChi Code: InChI=1S/C27H46O2/c1-20(2)10-7-11-21(3)12-8-13-22(4)14-9-16-27(6)17-15-24-19-25(28)18-23(5)26(24)29-27/h18-22,28H,7-17H2,1-6H3/t21-,22-,27-/m0/s1
SMILES Code: CC1=C2C(CC[C@@](O2)(CCC[C@H](CCC[C@H](CCCC(C)C)C)C)C)=CC(O)=C1
Appearance: Liquid
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 402.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
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| In vivo protocol: |
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2: Kelly MJ, Mathie AZ, Vallance C. A pharmacological action of vitamin E unrelated to its antioxidant capacity. Methods Find Exp Clin Pharmacol. 2006 Oct;28(8):499-505. doi: 10.1358/mf.2006.28.8.1003577. PMID: 17136228.
3: Sharpless KE, Schiller SB, Margolis SA, Thomas JB, Iyengar GV, Colbert JC, Gills TE, Wise SA, Tanner JT, Wolf WR. Certification of nutrients in Standard Reference Material 1846: infant formula. J AOAC Int. 1997 May-Jun;80(3):611-21. PMID: 9170657.
4: Chiku S, Hamamura K, Nakamura T. Novel urinary metabolite of d-delta- tocopherol in rats. J Lipid Res. 1984 Jan;25(1):40-8. PMID: 6707520.
5: Leth T, Sondergaard H. Biological activity of vitamin E compounds and natural materials by the resorption-gestation test, and chemical determination of the vitamin E activity in foods and feeds. J Nutr. 1977 Dec;107(12):2236-43. doi: 10.1093/jn/107.12.2236. PMID: 925769.
