WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H207149
CAS#: 2446010-87-1
Description: Doxy-Myr is a Myristoyl Amide Derivative of Doxycycline, which potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis. Doxy-Myr is >5-fold more potent than Doxycycline, as it appears to be better retained in cells, within a peri-nuclear membranous compartment. Moreover, Doxy-Myr did not affect the viability of the total MCF7 cancer cell population or normal fibroblasts grown as 2D-monolayers, showing remarkable selectivity for CSCs. Doxy-Myr can effectively minimize the risk of driving antibiotic resistance.
Hodoodo Cat#: H207149
Name: Doxy-Myr
CAS#: 2446010-87-1
Chemical Formula: C36H51N3O9
Exact Mass: 669.36
Molecular Weight: 669.816
Elemental Analysis: C, 64.55; H, 7.67; N, 6.27; O, 21.50
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Synonym: Doxy-Myr, Myristoyl Amide Derivative of Doxycycline; Myristoyl-Doxycycline; Doxycycline-Myristoyl;
IUPAC/Chemical Name: (4S,5S,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-9-(tetradecanoylamino)-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
InChi Key: OURBXAXWVFZPAC-UGLIEURDSA-N
InChi Code: InChI=1S/C36H51N3O9/c1-5-6-7-8-9-10-11-12-13-14-15-16-22(40)38-21-18-17-20-19(2)23-25(30(42)24(20)29(21)41)33(45)36(48)27(31(23)43)28(39(3)4)32(44)26(34(36)46)35(37)47/h17-19,23,27-28,31,41,43-45,48H,5-16H2,1-4H3,(H2,37,47)(H,38,40)/t19-,23?,27?,28-,31-,36-/m0/s1
SMILES Code: O=C(C1=C(O)[C@@H](N(C)C)C([C@@H](O)C2C(C(C3=C(O)C(NC(CCCCCCCCCCCCC)=O)=CC=C3[C@@H]2C)=O)=C4O)[C@@]4(O)C1=O)N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Doxy-Myr, lack antibiotic activity, but more potently target CSCs and effectively prevent metastasis, in an in vivo pre-clinical model. Therefore, Doxy-Myr could be used to eradicate CSCs, without exerting the selective pressures required for the development of antimicrobial resistance and without significant toxicity.
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| Soluble in DMSO | 0.0 | 100.00 |
The following data is based on the product molecular weight 669.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Ózsvári B, Magalhães LG, Latimer J, Kangasmetsa J, Sotgia F, Lisanti MP. A Myristoyl Amide Derivative of Doxycycline Potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis, Without Retaining Antibiotic Activity. Front Oncol. 2020 Sep 15;10:1528. doi: 10.3389/fonc.2020.01528. PMID: 33042796; PMCID: PMC7523513. https://www.frontiersin.org/articles/10.3389/fonc.2020.01528/full
