WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H412149
CAS#: 314-03-4
Description: Pimethixene or Calmixen is antihistamine and anticholinergic of the thioxanthene chemical class that is often used to treat hyperactivity, anxiety, sleep disorders, and allergy. It is also used for anesthesia and as a bronchodilator (to dilate the bronchi and bronchioles for more airflow).
Hodoodo Cat#: H412149
Name: Pimethixene
CAS#: 314-03-4
Chemical Formula: C19H19NS
Exact Mass: 293.12
Molecular Weight: 293.420
Elemental Analysis: C, 77.77; H, 6.53; N, 4.77; S, 10.93
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Pimethixene; BP 400; BP-400; BP400; Calmixen
IUPAC/Chemical Name: 1-Methyl-4-(thioxanthen-9-ylidene)piperidine
InChi Key: NZLVRVYNQYGMAB-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H19NS/c1-20-12-10-14(11-13-20)19-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)19/h2-9H,10-13H2,1H3
SMILES Code: CN1CC/C(CC1)=C2C3=C(SC4=C\2C=CC=C4)C=CC=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 293.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Ding L, Zhao D, Zhou T, Jiang WK, Xiao CH. [Specific PCR Molecular Identification of Euconunmia Cortex]. Zhong Yao Cai. 2015 Apr;38(4):730-4. Chinese. PMID: 26672337.
2: Schmitz B, Ullmer C, Segelcke D, Gwarek M, Zhu XR, Lübbert H. BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80. doi: 10.1016/j.ejphar.2015.01.043. Epub 2015 Feb 7. PMID: 25666387.
3: Soulère L, Sabbah M, Fontaine F, Queneau Y, Doutheau A. LuxR-dependent quorum sensing: computer aided discovery of new inhibitors structurally unrelated to N-acylhomoserine lactones. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4355-8. doi: 10.1016/j.bmcl.2010.06.081. Epub 2010 Jun 17. PMID: 20615699.
4: Chefneux A. Nouvelle thérapeutique de l'hyperkinésie chez l'enfant: le piméthixène [New treatment of hyperkinesis in the child: pimethixene]. Rev Med Liege. 1978 Jul 15;33(14):500-3. French. PMID: 674966.
5: Engelhardt G. Zur Pharmakologie des 9,10-Dihydro-10-(1-methyl-4-piperidyliden)-9-anthrol (WA 335), eines Histamin- und Serotoninantagonisten [On the pharmacology of 9,10-dihydro-10-(1-methyl-4-piperidylidene)-9-anthrol (WA 335), a histamine and serotonin antagonist (author's transl)]. Arzneimittelforschung. 1975 Nov;25(11):1723-37. German. PMID: 1049.
6: Du Pan RM, Vuille G. A propos de la différence de sensibilité aux sédatifs entre le nourrisson et l'enfant d'âge scolaire. Etude d'un nouveau sédatif, le BP 400 [Difference in sensitivity to sedative drugs between infant and child of school age. Study of a new sedative, BP 400 (author's transl)]. Schweiz Rundsch Med Prax. 1975 Aug 19;64(33):1050-7. French. PMID: 1161751.
7: Alder A. Klinische Erfahrungen mit der Anwendung von Pimethixen in der Prämedikation bei Kindern [Clinical experience with the application of pimethixene in the premedication of children]. Anaesthesist. 1967 Sep;16(9):279-80. German. PMID: 4384909.
8: PATRIGNANI S, LADI MP, CAFFARINI E. PRIMI RILIEVI SULL'IMPIEGO DEL 9-(N-METIL-PIPERIDILIDEN-4')-TIOXANTENE (BP400) NELL TRATTAMENTO DELL'INSUFFICIENZA RESPIRATORIA OSTRUTTIVA [PRELIMINARY FINDINGS ON THE USE OF 9-(METHYL-4'-PIPERIDYLIDENE)-THIOXANTHENE (BP 400) IN THE TREATMENT OF OBSTRUCTIVE RESPIRATORY INSUFFICIENCY]. Riv Crit Clin Med. 1963 Oct;63:351-60. Italian. PMID: 14279395.
9: GIRARD JP. [Clinical trials of a new antiallergic substance, 9-(N-methyl-4-piperidylidene)-thioxasthene (BP 400)]. Schweiz Med Wochenschr. 1963 Mar 16;93:446-9. French. PMID: 13948138.
10: GIRARD JP. PROPRI'ET'ES ANTIANAPHYLACTIQUES DU 9-(N-M'ETHYLPIPERIDYLIDEN-4') THIOXANTHEN (BP 400) ET DU LYSOZYME, COMPAR'EES 'A CELLES DE LA PREDNISONE [ANTIANAPHYLACTIC PROPERTIES OF 9-(N-METHYL-4'-PIPERIDYLIDENE) THIOXANTHENE (BP 400) AND LYSOZYME, COMPARED TO THOSE OF PREDNISONE]. Med Exp Int J Exp Med. 1963;9:400-8. French. PMID: 14084232.
11: MUITTARI A. BP 400 IN BRONCHIAL ASTHMA. Acta Allergol. 1963;18:263-70. doi: 10.1111/j.1398-9995.1963.tb03180.x. PMID: 14059854.
