WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H463162
CAS#: 59403-54-2
Description: 1-Palmitoyl-2-docosahexaenoyl-sn-glycero-3-PC (PDPC) is a phospholipid that contains palmitic acid and docosahexaenoic acid at the sn-1 and sn-2 positions, respectively. It is a component of LDL and HDL and has been found in atherosclerotic plaques. Enrichment of PDPC in recombinant HDLs decreases cholesterol ester formation by lecithin:cholesterol acyltransferase (LCAT) in vitro.
Hodoodo Cat#: H463162
Name: PDPC
CAS#: 59403-54-2
Chemical Formula: C46H80NO8P
Exact Mass: 805.56
Molecular Weight: 806.119
Elemental Analysis: C, 68.54; H, 10.00; N, 1.74; O, 15.88; P, 3.84
Synonym: 1-Palmitoyl-2-Docosahexaenoyl-sn-glycero-3-PC; 1-Palmitoyl-2-Docosahexaenoyl-sn-glycero-3-Phosphocholine; 1-Palmitoyl-2-Docosahexaenoyl-sn-glycero-3-Phosphatidylcholine; PC(16:0/22:6); 16:0/22:6-PC; PDPC;
IUPAC/Chemical Name: (R)-2-(((4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl)oxy)-3-(palmitoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
InChi Key: IESVDEZGAHUQJU-ZLBXKVHBSA-N
InChi Code: InChI=1S/C46H80NO8P/c1-6-8-10-12-14-16-18-20-21-22-23-24-25-27-29-31-33-35-37-39-46(49)55-44(43-54-56(50,51)53-41-40-47(3,4)5)42-52-45(48)38-36-34-32-30-28-26-19-17-15-13-11-9-7-2/h8,10,14,16,20-21,23-24,27,29,33,35,44H,6-7,9,11-13,15,17-19,22,25-26,28,30-32,34,36-43H2,1-5H3/b10-8-,16-14-,21-20-,24-23-,29-27-,35-33-/t44-/m1/s1
SMILES Code: O=C(CCCCCCCCCCCCCCC)OC[C@H](COP([O-])(OCC[N+](C)(C)C)=O)OC(CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 806.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Marquardt D, Heberle FA, Pan J, Cheng X, Pabst G, Harroun TA, Kučerka N, Katsaras J. The structures of polyunsaturated lipid bilayers by joint refinement of neutron and X-ray scattering data. Chem Phys Lipids. 2020 Jul;229:104892. doi: 10.1016/j.chemphyslip.2020.104892. Epub 2020 Feb 12. PMID: 32061581.
2: Wassall SR, Leng X, Canner SW, Pennington ER, Kinnun JJ, Cavazos AT, Dadoo S, Johnson D, Heberle FA, Katsaras J, Shaikh SR. Docosahexaenoic acid regulates the formation of lipid rafts: A unified view from experiment and simulation. Biochim Biophys Acta Biomembr. 2018 Oct;1860(10):1985-1993. doi: 10.1016/j.bbamem.2018.04.016. Epub 2018 May 3. PMID: 29730243; PMCID: PMC6218320.
3: Kinnun JJ, Bittman R, Shaikh SR, Wassall SR. DHA Modifies the Size and Composition of Raftlike Domains: A Solid-State 2H NMR Study. Biophys J. 2018 Jan 23;114(2):380-391. doi: 10.1016/j.bpj.2017.11.023. PMID: 29401435; PMCID: PMC5984975.
4: Ausili A, de Godos AM, Torrecillas A, Aranda FJ, Corbalán-García S, Gómez- Fernández JC. The vertical location of α-tocopherol in phosphatidylcholine membranes is not altered as a function of the degree of unsaturation of the fatty acyl chains. Phys Chem Chem Phys. 2017 Mar 1;19(9):6731-6742. doi: 10.1039/c6cp08872d. PMID: 28211935.
5: Al Sazzad MA, Slotte JP. Effect of Phosphatidylcholine Unsaturation on the Lateral Segregation of Palmitoyl Ceramide and Palmitoyl Dihydroceramide in Bilayer Membranes. Langmuir. 2016 Jun 14;32(23):5973-80. doi: 10.1021/acs.langmuir.6b00859. Epub 2016 Jun 1. PMID: 27218704.
