WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H463168
CAS#: 14941-08-3
Description: Poncirin is a flavonoid glycoside that has been found in P. trifoliata and has diverse biological activities. It inhibits the growth of SGC-7901 gastric cancer cells when used at concentrations ranging from 5 to 25 µg/ml. Poncirin inhibits LPS-induced NF-κB DNA-binding activity, as well as production of nitric oxide and prostaglandin E2 in RAW 264.7 cells. It reduces the gastric ulcer lesion index in a rat model of HCl/ethanol-induced gastritis when administered at doses of 50 and 100 mg/kg.
Hodoodo Cat#: H463168
Name: Poncirin
CAS#: 14941-08-3
Chemical Formula: C28H34O14
Exact Mass: 594.19
Molecular Weight: 594.566
Elemental Analysis: C, 56.56; H, 5.76; O, 37.67
Synonym: Poncirin;
IUPAC/Chemical Name: (S)-7-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-2-(4-methoxyphenyl)chroman-4-one
InChi Key: NLAWPKPYBMEWIR-SKYQDXIQSA-N
InChi Code: InChI=1S/C28H34O14/c1-11-21(32)23(34)25(36)27(38-11)42-26-24(35)22(33)19(10-29)41-28(26)39-14-7-15(30)20-16(31)9-17(40-18(20)8-14)12-3-5-13(37-2)6-4-12/h3-8,11,17,19,21-30,32-36H,9-10H2,1-2H3/t11-,17-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1
SMILES Code: O=C1C2=C(O)C=C(O[C@@H]([C@H](O[C@@]([H])([C@H](O)[C@H](O)[C@H]3O)O[C@H]3C)[C@@H](O)[C@@H]4O)O[C@@H]4CO)C=C2O[C@@H](C1)C5=CC=C(OC)C=C5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 594.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
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2: Zhao L, Zhang W, Zhang F. Poncirin downregulates ATP-binding cassette transporters to enhance cisplatin sensitivity in cisplatin-resistant osteosarcoma cells. Phytother Res. 2020 Aug 11. doi: 10.1002/ptr.6798. Epub ahead of print. PMID: 32779800.
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4: Yousof Ali M, Zaib S, Mizanur Rahman M, Jannat S, Iqbal J, Kyu Park S, Seog Chang M. Poncirin, an orally active flavonoid exerts antidiabetic complications and improves glucose uptake activating PI3K/Akt signaling pathway in insulin resistant C2C12 cells with anti-glycation capacities. Bioorg Chem. 2020 Sep;102:104061. doi: 10.1016/j.bioorg.2020.104061. Epub 2020 Jun 30. PMID: 32653611.
5: Ullah H, Khan A, Baig MW, Ullah N, Ahmed N, Tipu MK, Ali H, Khan S. Poncirin attenuates CCL4-induced liver injury through inhibition of oxidative stress and inflammatory cytokines in mice. BMC Complement Med Ther. 2020 Apr 19;20(1):115. doi: 10.1186/s12906-020-02906-7. PMID: 32307011; PMCID: PMC7168870.
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