WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H574935
CAS#: 19881-70-0
Description: Windorphen is a cell-permeable bis(4-methoxyphenyl)chloroacrylaldehyde whose (Z)-isomer (isomeric content 12-15%) acts as a p300-selective histone acetytransferase (HAT) inhibitor.
Hodoodo Cat#: H574935
Name: Windorphen
CAS#: 19881-70-0
Chemical Formula: C17H15ClO3
Exact Mass: 302.07
Molecular Weight: 302.750
Elemental Analysis: C, 67.44; H, 4.99; Cl, 11.71; O, 15.85
Synonym: Histone Acetyltransferase Inhibitor XII; Windorphen; WD, HAT Inhibitor XII, Wnt Pathway Inhibitor XXII
IUPAC/Chemical Name: ( E) & ( Z)-3-Chloro-2,3- bis(4-methoxyphenyl)acrylaldehyde
InChi Key: VNRALGZMXHFBPG-MSUUIHNZSA-N
InChi Code: InChI=1S/C17H15ClO3/c1-20-14-7-3-12(4-8-14)16(11-19)17(18)13-5-9-15(21-2)10-6-13/h3-11H,1-2H3/b17-16-
SMILES Code: O=C/C(C1=CC=C(OC)C=C1)=C(Cl)\C2=CC=C(OC)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 302.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Hao J, Ao A, Zhou L, Murphy CK, Frist AY, Keel JJ, Thorne CA, Kim K, Lee E, Hong CC. Selective small molecule targeting β-catenin function discovered by in vivo chemical genetic screen. Cell Rep. 2013 Sep 12;4(5):898-904. doi: 10.1016/j.celrep.2013.07.047. Epub 2013 Sep 5. PMID: 24012757; PMCID: PMC3923627.