WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H535763
CAS#: 142062-87-1
Description: Pradimicin L is a biaoctive chemical.
Hodoodo Cat#: H535763
Name: Pradimicin L
CAS#: 142062-87-1
Chemical Formula: C41H46N2O19
Exact Mass: 870.27
Molecular Weight: 870.814
Elemental Analysis: C, 56.55; H, 5.32; N, 3.22; O, 34.91
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Synonym: Pradimicin L
IUPAC/Chemical Name: D-Alanine, N-((5-((4,6-dideoxy-3-O-beta-D-glucopyranosyl-4-(methylamino)-beta-D-galactopyranosyl)oxy)-5,6,8,13-tetrahydro-1,6,9,14-tetrahydroxy-11-methoxy-3-methyl-8,13-dioxobenzo(a)naphthacen-2-yl)carbonyl)-, (5S-trans)-
InChi Key: GHJAVLVTKGUJCU-HBYOQVLJSA-N
InChi Code: InChI=1S/C41H46N2O19/c1-11-6-18-24(31(50)21(11)38(55)43-12(2)39(56)57)23-16(9-17-25(32(23)51)28(47)15-7-14(58-5)8-19(45)22(15)27(17)46)29(48)36(18)61-41-35(54)37(26(42-4)13(3)59-41)62-40-34(53)33(52)30(49)20(10-44)60-40/h6-9,12-13,20,26,29-30,33-37,40-42,44-45,48-54H,10H2,1-5H3,(H,43,55)(H,56,57)/t12-,13-,20-,26+,29+,30-,33+,34-,35-,36+,37+,40+,41+/m1/s1
SMILES Code: C[C@H](C(O)=O)NC(C1=C(C)C=C([C@H](O[C@H]2[C@@H]([C@H]([C@@H](NC)[C@@H](C)O2)O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)O)[C@@H](O)C(C=C4C(C5=C6C=C(OC)C=C5O)=O)=C7C(O)=C4C6=O)C7=C1O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 870.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Saitoh K, Tsuno T, Kakushima M, Hatori M, Furumai T, Oki T. Pradimicin S, a new pradimicin analog. II. Isolation and structure elucidation. J Antibiot (Tokyo). 1993 Mar;46(3):406-11. doi: 10.7164/antibiotics.46.406. PMID: 8267791.
2: Hiramoto F, Nomura N, Furumai T, Igarashi Y, Oki T. Pradimicin-resistance of yeast is caused by a point mutation of the histidine-containing phosphotransfer protein Ypd1. J Antibiot (Tokyo). 2003 Dec;56(12):1053-7. doi: 10.7164/antibiotics.56.1053. PMID: 15015733.
3: Saitoh K, Furumai T, Oki T, Nishida F, Harada K, Suzuki M. Pradimicin S, a new pradimicin analog. III. Application of the frit-FAB LC/MS technique to the elucidation of the pradimicin S biosynthetic pathway. J Antibiot (Tokyo). 1995 Feb;48(2):162-8. doi: 10.7164/antibiotics.48.162. PMID: 7706128.
4: Saitoh K, Sawada Y, Tomita K, Tsuno T, Hatori M, Oki T. Pradimicins L and FL: new pradimicin congeners from Actinomadura verrucosospora subsp. neohibisca. J Antibiot (Tokyo). 1993 Mar;46(3):387-97. doi: 10.7164/antibiotics.46.387. PMID: 8478257.