WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H463321
CAS#: 1426293-61-9
Description: PAM-2 is a novel positive allosteric modulator of α7 nAChRs, decreasing STZ-induced neuropathic pain and chemotherapy-induced neuropathic pain.
Hodoodo Cat#: H463321
Name: PAM-2
CAS#: 1426293-61-9
Chemical Formula: C14H13NO2
Exact Mass: 227.09
Molecular Weight: 227.263
Elemental Analysis: C, 73.99; H, 5.77; N, 6.16; O, 14.08
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Synonym: PAM-2; PAM2; PAM 2;
IUPAC/Chemical Name: (E)-3-(furan-2-yl)-N-(p-tolyl)acrylamide
InChi Key: DJMZLFDVBHWQTH-CMDGGOBGSA-N
InChi Code: InChI=1S/C14H13NO2/c1-11-4-6-12(7-5-11)15-14(16)9-8-13-3-2-10-17-13/h2-10H,1H3,(H,15,16)/b9-8+
SMILES Code: O=C(NC1=CC=C(C)C=C1)/C=C/C2=CC=CO2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 227.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Phenis D, Vunck SA, Valentini V, Arias H, Schwarcz R, Bruno JP. Activation of alpha7 nicotinic and NMDA receptors is necessary for performance in a working memory task. Psychopharmacology (Berl). 2020 Jun;237(6):1723-1735. doi: 10.1007/s00213-020-05495-y. Epub 2020 Mar 11. PMID: 32162104; PMCID: PMC7313359.
2: Arias HR, Ghelardini C, Lucarini E, Tae HS, Yousuf A, Marcovich I, Manetti D, Romanelli MN, Elgoyhen AB, Adams DJ, Di Cesare Mannelli L. (E)-3-Furan-2-yl-N-p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation. ACS Chem Neurosci. 2020 Nov 4;11(21):3603-3614. doi: 10.1021/acschemneuro.0c00476. Epub 2020 Oct 19. PMID: 33073974.