WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H412466
CAS#: 1010396-29-8
Description: S-23 is an androgen receptor modulator.
Hodoodo Cat#: H412466
Name: S-23
CAS#: 1010396-29-8
Chemical Formula: C18H13ClF4N2O3
Exact Mass: 416.06
Molecular Weight: 416.760
Elemental Analysis: C, 51.88; H, 3.14; Cl, 8.51; F, 18.23; N, 6.72; O, 11.52
Synonym: S-23; S23; S 23
IUPAC/Chemical Name: (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide
InChi Key: SSFVOEAXHZGTRJ-KRWDZBQOSA-N
InChi Code: InChI=1S/C18H13ClF4N2O3/c1-17(27,9-28-12-4-5-14(19)15(20)7-12)16(26)25-11-3-2-10(8-24)13(6-11)18(21,22)23/h2-7,27H,9H2,1H3,(H,25,26)/t17-/m0/s1
SMILES Code: C[C@](COc1cc(F)c(Cl)cc1)(C(Nc2cc(C(F)(F)F)c(C#N)cc2)=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 416.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Fang C, Li L, He R, Wang D, Wang M, Hu Q, Ma Q, Qin K, Feng X, Zhang G, Fu X, Liu Z. Identification of S23 causing both interspecific hybrid male sterility and environment-conditioned male sterility in rice. Rice (N Y). 2019 Feb 28;12(1):10. doi: 10.1186/s12284-019-0271-4. PMID: 30820693; PMCID: PMC6395467.
2: Burkle C. S23. The Father (and Lawyer) of Intravenous Therapy. J Anesth Hist. 2015 Jul;1(3):97. doi: 10.1016/j.janh.2015.07.025. Epub 2015 Sep 20. PMID: 26930105.
3: Geyer SH, Reissig LF, Hüsemann M, Höfle C, Wilson R, Prin F, Szumska D, Galli A, Adams DJ, White J, Mohun TJ, Weninger WJ. Morphology, topology and dimensions of the heart and arteries of genetically normal and mutant mouse embryos at stages S21-S23. J Anat. 2017 Oct;231(4):600-614. doi: 10.1111/joa.12663. Epub 2017 Aug 3. PMID: 28776665; PMCID: PMC5603791.
4: Kitaoka Y, Olvera J, Wool IG. The primary structure of rat ribosomal protein S23. Biochem Biophys Res Commun. 1994 Jul 15;202(1):314-20. doi: 10.1006/bbrc.1994.1929. PMID: 8037726.
5: Malik A, Kimchhayarasy P, Kakii K. Effect of surfactants on stability of Acinetobacter johnsonii S35 and Oligotropha carboxidovorans S23 coaggregates. FEMS Microbiol Ecol. 2005 Feb 1;51(3):313-21. doi: 10.1016/j.femsec.2004.09.005. PMID: 16329879.
6: Pandey SK, Narayan KD, Bandyopadhyay S, Nayak KC, Das SK. Thiosulfate oxidation by Comamonas sp. S23 isolated from a sulfur spring. Curr Microbiol. 2009 May;58(5):516-21. doi: 10.1007/s00284-009-9357-3. Epub 2009 Feb 3. PMID: 19189181.
7: Wang T, Hou Y, Ding X, Song B, Wang F, Hou W. Overexpression, purification, molecular characterization and pharmacological evaluation for anticancer activity of ribosomal protein S23 from the giant panda (Ailuropoda melanoleuca). Mol Med Rep. 2013 Jun;7(6):1875-82. doi: 10.3892/mmr.2013.1430. Epub 2013 Apr 16. PMID: 23591681.
8: Li X, Zhang SC, Liu ZH, Li HY. Ribosomal protein genes S23 and L35 from amphioxus Branchiostoma belcheri tsingtauense: identification and copy number. Acta Biochim Biophys Sin (Shanghai). 2005 Aug;37(8):573-9. doi: 10.1111/j.1745-7270.2005.00072.x. PMID: 16077906.
9: Collatz E, Wool IG, Lin A, Stöffler G. The isolation of eukaryotic ribosomal proteins. The purification and characterization of the 40 S ribosomal subunit proteins S2, S3, S4, S5, S6, S7, S8, S9, S13, S23/S24, S27, and S28. J Biol Chem. 1976 Aug 10;251(15):4666-72. PMID: 947902.
10: Pu M, Wang J, Huang Q, Zhao G, Xia C, Shang R, Zhang Z, Bian Z, Yang X, Tao K. High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes. Tumour Biol. 2017 Jul;39(7):1010428317709127. doi: 10.1177/1010428317709127. PMID: 28714366.
