WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H412670
CAS#: 3700-67-2
Description: Incorporation of the glycolipid trehalose 6,6'-dibehenate (TDB) into cationic liposomes composed of the quaternary ammonium compound dimethyldioctadecylammonium (DDA) produce an adjuvant system which induces a powerful cell-mediated immune response and a strong antibody response, desirable for a high number of disease targets.
Hodoodo Cat#: H412670
Name: PUM00672
CAS#: 3700-67-2
Chemical Formula: C38H80BrN
Exact Mass: 629.55
Molecular Weight: 630.970
Elemental Analysis: C, 72.34; H, 12.78; Br, 12.66; N, 2.22
Synonym: 18:0 DDAB; Dimethyldioctadecylammonium (Bromide Salt); PUM-00672; PUM 00672; PUM00672
IUPAC/Chemical Name: N,N-dimethyl-N-octadecyloctadecan-1-aminium bromide
InChi Key: PSLWZOIUBRXAQW-UHFFFAOYSA-M
InChi Code: InChI=1S/C38H80N.BrH/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-39(3,4)38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2;/h5-38H2,1-4H3;1H/q+1;/p-1
SMILES Code: CCCCCCCCCCCCCCCCCC[N+](CCCCCCCCCCCCCCCCCC)(C)C.[Br-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 630.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Iwasaki F, Suga K, Okamoto Y, Umakoshi H. Characterization of DDAB/Cholesterol Vesicles and Its Comparison with Lipid/Cholesterol Vesicles. J Nanosci Nanotechnol. 2018 Mar 1;18(3):1989-1994. doi: 10.1166/jnn.2018.14252. PMID: 29448697.
2: Carbone C, Martins-Gomes C, Pepe V, Silva AM, Musumeci T, Puglisi G, Furneri PM, Souto EB. Repurposing itraconazole to the benefit of skin cancer treatment: A combined azole-DDAB nanoencapsulation strategy. Colloids Surf B Biointerfaces. 2018 Jul 1;167:337-344. doi: 10.1016/j.colsurfb.2018.04.031. Epub 2018 Apr 17. PMID: 29684903.
3: Zhang Y, Wang Z, Gemeinhart RA. Progress in microRNA delivery. J Control Release. 2013 Dec 28;172(3):962-74. doi: 10.1016/j.jconrel.2013.09.015. Epub 2013 Sep 25. PMID: 24075926; PMCID: PMC3891846.
4: Correia B, Lourenço J, Marques S, Nogueira V, Gavina A, da Graça Rasteiro M, Antunes F, Mendo S, Pereira R. Oxidative stress and genotoxicity of an organic and an inorganic nanomaterial to Eisenia andrei: SDS/DDAB nano-vesicles and titanium silicon oxide. Ecotoxicol Environ Saf. 2017 Jun;140:198-205. doi: 10.1016/j.ecoenv.2017.02.035. Epub 2017 Mar 8. PMID: 28260685.
5: Domenici F, Castellano C, Dell'unto F, Congiu A. Temperature-dependent structural changes on DDAB surfactant assemblies evidenced by energy dispersive X-ray diffraction and dynamic light scattering. Colloids Surf B Biointerfaces. 2012 Jun 15;95:170-7. doi: 10.1016/j.colsurfb.2012.02.037. Epub 2012 Mar 3. PMID: 22429784.
6: Manosroi A, Thathang K, Manosroi J, Werner RG, Schubert R, Peschka-Süss R. Expression of luciferase plasmid (pCMVLuc) entrapped in DPPC/cholesterol/DDAB liposomes in HeLa cell lines. J Liposome Res. 2009;19(2):131-40. doi: 10.1080/08982100802642457. PMID: 19515000.
7: Lee CY, Bond AM. A comparison of the higher order harmonic components derived from large-amplitude Fourier transformed ac voltammetry of myoglobin and heme in DDAB films at a pyrolytic graphite electrode. Langmuir. 2010 Apr 6;26(7):5243-53. doi: 10.1021/la903387n. PMID: 20232815.
8: Jantafong T, Ruenphet S, Punyadarsaniya D, Takehara K. The study of effect of didecyl dimethyl ammonium bromide on bacterial and viral decontamination for biosecurity in the animal farm. Vet World. 2018 May;11(5):706-711. doi: 10.14202/vetworld.2018.706-711. Epub 2018 May 27. PMID: 29915512; PMCID: PMC5993774.
9: Kusumoto K, Ishikawa T. Didodecyldimethylammonium bromide (DDAB) induces caspase-mediated apoptosis in human leukemia HL-60 cells. J Control Release. 2010 Oct 15;147(2):246-52. doi: 10.1016/j.jconrel.2010.07.114. Epub 2010 Jul 30. PMID: 20674638.
10: Lin W, Guan X, Cao J, Niu B, Chen Q. Bactericidal mechanism of glutaraldehyde-didecyldimethylammonium bromide as a disinfectant against Escherichia coli. J Appl Microbiol. 2017 Mar;122(3):676-685. doi: 10.1111/jam.13384. Epub 2017 Jan 25. PMID: 27997750.