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PGB1
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H412681

CAS#: 13345-51-2

Description: PGB1 is a metabolite of PGA1 shown to modify the pressor responses to sympathetic nerve stimulation

Chemical Structure

PGB1

CAS# 13345-51-2

Instruction

Theoretical Analysis

Hodoodo Cat#: H412681
Name: PGB1
CAS#: 13345-51-2
Chemical Formula: C20H32O4
Exact Mass: 336.23
Molecular Weight: 336.472
Elemental Analysis: C, 71.39; H, 9.59; O, 19.02

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 274	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: PGB1; Prostaglandin B1

IUPAC/Chemical Name: (S,E)-7-(2-(3-hydroxyoct-1-en-1-yl)-5-oxocyclopent-1-en-1-yl)heptanoic acid

InChi Key: YBHMPNRDOVPQIN-VSOYFRJCSA-N

InChi Code: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1

SMILES Code: O=C1C(CCCCCCC(O)=O)=C(/C=C/[C@H](CCCCC)O)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 336.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yeo J, Lee YH, Jeon SM, Jung UJ, Lee MK, Jung YM, Choi MS. Supplementation of a novel microbial biopolymer, PGB1, from new Enterobacter sp. BL-2 delays the deterioration of type 2 diabetic mice. J Microbiol Biotechnol. 2007 Dec;17(12):1983-90. PMID: 18167446.

2: Bruce PG, Freunberger SA, Hardwick LJ, Tarascon JM. Li-O2 and Li-S batteries with high energy storage. Nat Mater. 2011 Dec 15;11(1):19-29. doi: 10.1038/nmat3191. Erratum in: Nat Mater. 2012 Feb;11(2):172. PMID: 22169914.

3: Franson RC, Rosenthal MD, Regelson W. Mechanism(s) of cytoprotective and anti-inflammatory activity of PGB1 oligomers: PGBx has potent anti-phospholipase A2 and anti-oxidant activity. Prostaglandins Leukot Essent Fatty Acids. 1991 Jun;43(2):63-70. doi: 10.1016/0952-3278(91)90173-3. PMID: 1886908.

4: Lindman S, Linse S, Mulder FA, André I. pK(a) values for side-chain carboxyl groups of a PGB1 variant explain salt and pH-dependent stability. Biophys J. 2007 Jan 1;92(1):257-66. doi: 10.1529/biophysj.106.088682. Epub 2006 Oct 13. Erratum in: Biophys J. 2009 May 6;96(9):3886. PMID: 17040982; PMCID: PMC1697841.

5: DeTitta GT, Langs DA, Edmonds JW. Prostaglandins PGA1 and PGB1. Crystallographic studies of the conformational requirements for 15-hydroxyprostaglandin dehydrogenase activity. Biochemistry. 1979 Jul 24;18(15):3387-91. doi: 10.1021/bi00582a027. PMID: 465479.

6: Mira MM, Ciacka K, Hill RD, Stasolla C. In vitro differentiation of tracheary elements is induced by suppression of Arabidopsis phytoglobins. Plant Physiol Biochem. 2019 Feb;135:141-148. doi: 10.1016/j.plaphy.2018.11.036. Epub 2018 Nov 29. PMID: 30529980.

7: Bille A, Jensen KS, Mohanty S, Akke M, Irbäck A. Stability and Local Unfolding of SOD1 in the Presence of Protein Crowders. J Phys Chem B. 2019 Mar 7;123(9):1920-1930. doi: 10.1021/acs.jpcb.8b10774. Epub 2019 Feb 26. PMID: 30753785.

8: Suzuki Y, Kurakata E, Yoshida A, Kobayashi A, Park MK. Molecular identification of single hormone-encoding proglucagon cDNA isoforms from squamates and their abundant expression. Gene. 2018 Oct 30;675:322-331. doi: 10.1016/j.gene.2018.07.011. Epub 2018 Jul 4. PMID: 29981418.

9: Pike JE. Total synthesis of prostaglandins. Fortschr Chem Org Naturst. 1970;28:313-42. doi: 10.1007/978-3-7091-7123-3_7. PMID: 4950982.

10: Zafari S, Hebelstrup KH, Igamberdiev AU. Transcriptional and Metabolic Changes Associated with Phytoglobin Expression during Germination of Barley Seeds. Int J Mol Sci. 2020 Apr 17;21(8):2796. doi: 10.3390/ijms21082796. PMID: 32316536; PMCID: PMC7215281.