WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H412695
CAS#: 122-32-7
Description: Triolein, also known as Triolein (18:1 TG), Glycerol trioleate, Glycerol triolein, Oleic acid triglyceride, Oleic triglyceride, is a nanoemulsion-derived glyceroltrioleate. Triolein has been used (1) as an experimental diet along with fat-free basal mix and corn oil and then to access the dietary fat absorption among mice; (2) as an interfering substance to test its effect on human serum in the approach to develop rapid enzyme immunoassay for the detection of retinol-binding protein; (3) as a standard in the determination of triglyceride concentration, colorimetrically using liver tissue sample from cows.
Hodoodo Cat#: H412695
Name: Triolein
CAS#: 122-32-7
Chemical Formula: C57H104O6
Exact Mass: 884.78
Molecular Weight: 885.450
Elemental Analysis: C, 77.32; H, 11.84; O, 10.84
Synonym: Triolein (18:1 TG); Glycerol trioleate, Glycerol triolein, Oleic acid triglyceride, Oleic triglyceride, TG(18:1(9Z)/18:1(9Z)/18:1(9Z)), Triolein
IUPAC/Chemical Name: (9Z)9-Octadecenoic acid 1,2,3-propanetriyl ester,
InChi Key: PHYFQTYBJUILEZ-IUPFWZBJSA-N
InChi Code: InChI=1S/C57H104O6/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-43-46-49-55(58)61-52-54(63-57(60)51-48-45-42-39-36-33-30-27-24-21-18-15-12-9-6-3)53-62-56(59)50-47-44-41-38-35-32-29-26-23-20-17-14-11-8-5-2/h25-30,54H,4-24,31-53H2,1-3H3/b28-25-,29-26-,30-27-
SMILES Code: [H]C(COC(CCCCCCC/C=C\CCCCCCCC)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 885.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Kim HJ, Kim YW, Choi SH, Cho BM, Bandu R, Ahn HS, Kim KP. Triolein Emulsion Infusion Into the Carotid Artery Increases Brain Permeability to Anticancer Agents. Neurosurgery. 2016 May;78(5):726-33. doi: 10.1227/NEU.0000000000001104. PMID: 26540353.
2: Stamm A, Svendsen A, Skjold-Jørgensen J, Vissing T, Berts I, Nylander T. The triolein/aqueous interface and lipase activity studied by spectroscopic ellipsometry and coarse grained simulations. Chem Phys Lipids. 2018 Mar;211:37-43. doi: 10.1016/j.chemphyslip.2017.10.011. Epub 2017 Nov 10. PMID: 29129569.
3: Yamaguchi T, Murano T, Tatsuno I, Hiruta N, Suzuki T, Sawada S, Katagiri H, Shirai K, Schneider WJ, Bujo H. Severely impaired activity of lipoprotein lipase Arg243His is partially ameliorated by emulsifying phospholipids in in vitro triolein hydrolysis analysis. Ann Clin Biochem. 2017 Nov;54(6):712-715. doi: 10.1177/0004563217693258. Epub 2017 Jan 23. PMID: 28114790.
4: Luo T, Deng ZY, Li XP, Rao H, Fan YW. Triolein and trilinolein ameliorate oxidized low-density lipoprotein-induced oxidative stress in endothelial cells. Lipids. 2014 May;49(5):495-504. doi: 10.1007/s11745-014-3889-4. Epub 2014 Mar 7. PMID: 24604600.
5: Lu Y, Wang Z, Huckins J. Review of the background and application of triolein-containing semipermeable membrane devices in aquatic environmental study. Aquat Toxicol. 2002 Oct 2;60(1-2):139-53. doi: 10.1016/s0166-445x(02)00056-5. PMID: 12204593.
6: Kim YW, Park YM, Yoon S, Kim HJ, Park DY, Cho BM, Choi SH. Effect of intra- arterial infusion with triolein emulsion on rabbit liver. World J Gastroenterol. 2014 Oct 21;20(39):14442-9. doi: 10.3748/wjg.v20.i39.14442. PMID: 25339830; PMCID: PMC4202372.
7: Kim HJ, Kim YW, Lee IS, Song JW, Jeong YJ, Choi SH, Choi KU, Suh KT, Cho BM. Intra-arterial delivery of triolein emulsion increases vascular permeability in skeletal muscles of rabbits. Acta Vet Scand. 2009 Jul 16;51(1):30. doi: 10.1186/1751-0147-51-30. PMID: 19604410; PMCID: PMC2717075.
8: Zhang Z, Fang X, Hao J, Li Y, Sha X. Triolein-based polycation lipid nanocarrier for efficient gene delivery: characteristics and mechanism. Int J Nanomedicine. 2011;6:2235-44. doi: 10.2147/IJN.S24720. Epub 2011 Oct 7. PMID: 22114487; PMCID: PMC3215164.
9: Abraham MH, Acree WE Jr. Equations for water-triolein partition coefficients for neutral species; comparison with other water-solvent partitions, and environmental and toxicological processes. Chemosphere. 2016 Jul;154:48-54. doi: 10.1016/j.chemosphere.2016.03.086. Epub 2016 Mar 31. PMID: 27038899.
10: Wang Z, Wang Y, Ma M, Lu Y, Huckins J. Use of triolein-semipermeable membrane devices to assess the bioconcentration and sediment sorption of hydrophobic organic contaminants in the Huaihe River, China. Environ Toxicol Chem. 2002 Nov;21(11):2378-84. PMID: 12389917.
