WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H463688
CAS#: 83858-82-6
Description: Piperazinomycin is an antifungal antibiotic, showing inhibitory activity against fungi and yeasts, especially against Trichophyton.
Hodoodo Cat#: H463688
Name: Piperazinomycin
CAS#: 83858-82-6
Chemical Formula: C18H20N2O2
Exact Mass: 296.15
Molecular Weight: 296.370
Elemental Analysis: C, 72.95; H, 6.80; N, 9.45; O, 10.80
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Synonym: Piperazinomycin;
IUPAC/Chemical Name: (12S,15S)-4-oxa-1(2,5)-piperazina-3(1,3),5(1,4)-dibenzenacyclohexaphan-34-ol
InChi Key: UOLONRFQMXQQFB-GJZGRUSLSA-N
InChi Code: InChI=1S/C18H20N2O2/c21-17-6-3-13-8-15-11-19-14(10-20-15)7-12-1-4-16(5-2-12)22-18(17)9-13/h1-6,9,14-15,19-21H,7-8,10-11H2/t14-,15-/m0/s1
SMILES Code: OC1=C(OC2=CC=C(C=C2)C[C@@H](CN3)NC[C@@H]3C4)C=C4C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 296.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Samanta K, Panda G. Regioselective ring-opening of amino acid-derived chiral aziridines: an easy access to cis-2,5-disubstituted chiral piperazines. Chem Asian J. 2011 Jan 3;6(1):189-97. doi: 10.1002/asia.201000554. PMID: 21077094.
2: Zhu J. S(N)Ar-based cycloetherification methodology: application in the synthesis of heterodectic macrocyclic peptides with endo aryl-aryl and aryl- alkyl ether bonds. Methods Mol Med. 1999;23:293-320. doi: 10.1385/0-89603-517-4:293. PMID: 21380904.
3: Beugelmans R, Bigot A, Bois-Choussy M, Zhu J. A New Approach to the Synthesis of Piperazinomycin and Bouvardin: Facile Access to Cycloisodityrosine via an Intramolecular S(N)Ar Reaction. J Org Chem. 1996 Jan 26;61(2):771-774. doi: 10.1021/jo951375j. PMID: 11667003.
4: Kaneda M, Tamai S, Nakamura S, Hirata T, Kushi Y, Suga T. Piperazinomycin, a new antifungal antibiotic. II. Structure determination by X-ray crystallography. J Antibiot (Tokyo). 1982 Sep;35(9):1137-40. doi: 10.7164/antibiotics.35.1137. PMID: 7142020.
5: Tamai S, Kaneda M, Nakamura S. Piperazinomycin, a new antifungal antibiotic. I. Fermentation, isolation, characterization and biological properties. J Antibiot (Tokyo). 1982 Sep;35(9):1130-6. doi: 10.7164/antibiotics.35.1130. PMID: 7142019.
