WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H463698
CAS#: unknown
Description: PF-06843195 is a potent and selective PI3Kα Inhibitor. The phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling pathway is a frequently dysregulated pathway in human cancer, and PI3Kα is one of the most frequently mutated kinases in human cancer. A PI3Kα-selective inhibitor may provide the opportunity to spare patients the side effects associated with broader inhibition of the class I PI3K family.
Hodoodo Cat#: H463698
Name: PF-06843195
CAS#: unknown
Chemical Formula: C20H25F3N8O4
Exact Mass: 498.20
Molecular Weight: 498.467
Elemental Analysis: C, 48.19; H, 5.06; F, 11.43; N, 22.48; O, 12.84
This product is not in stock, which may be available by custom synthesis.
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Synonym: PF-06843195; PF 06843195; PF06843195;
IUPAC/Chemical Name: 2,2-difluoroethyl (S)-3-((2'-amino-5-fluoro-2-morpholino-[4,5'-bipyrimidin]-6-yl)amino)-3-(hydroxymethyl)pyrrolidine-1-carboxylate
InChi Key: RTOREZYNLPQUKM-FQEVSTJZSA-N
InChi Code: InChI=1S/C20H25F3N8O4/c21-13(22)9-35-19(33)31-2-1-20(10-31,11-32)29-16-14(23)15(12-7-25-17(24)26-8-12)27-18(28-16)30-3-5-34-6-4-30/h7-8,13,32H,1-6,9-11H2,(H2,24,25,26)(H,27,28,29)/t20-/m0/s1
SMILES Code: NC1=NC=C(C2=C(F)C(N[C@]3(CO)CN(C(OCC(F)F)=O)CC3)=NC(N4CCOCC4)=N2)C=N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 498.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Cheng H, Orr STM, Bailey S, Brooun A, Chen P, Deal JG, Deng YL, Edwards MP, Gallego GM, Grodsky N, Huang B, Jalaie M, Kaiser S, Kania RS, Kephart SE, Lafontaine J, Ornelas MA, Pairish M, Planken S, Shen H, Sutton S, Zehnder L, Almaden CD, Bagrodia S, Falk MD, Gukasyan HJ, Ho C, Kang X, Kosa RE, Liu L, Spilker ME, Timofeevski S, Visswanathan R, Wang Z, Meng F, Ren S, Shao L, Xu F, Kath JC. Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195). J Med Chem. 2020 Dec 24. doi: 10.1021/acs.jmedchem.0c01652. Epub ahead of print. PMID: 33356246.
