WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H575956
CAS#: 77727-17-4
Description: Rigin is a Tuftsin-like tetrapeptide with equal phagocytosis stimulating activity.
Hodoodo Cat#: H575956
Name: Rigin
CAS#: 77727-17-4
Chemical Formula: C18H32N8O6
Exact Mass: 456.24
Molecular Weight: 456.500
Elemental Analysis: C, 47.36; H, 7.07; N, 24.55; O, 21.03
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Synonym: Gly-gln-pro-arg; GQPR; Rigin; Tetrapeptide-3; Tetrapeptide-7
IUPAC/Chemical Name: L-Arginine, N2-(1-(N2-glycyl-L-glutaminyl)-L-prolyl)-
InChi Key: UEJYSALTSUZXFV-SRVKXCTJSA-N
InChi Code: InChI=1S/C18H32N8O6/c19-9-14(28)24-10(5-6-13(20)27)16(30)26-8-2-4-12(26)15(29)25-11(17(31)32)3-1-7-23-18(21)22/h10-12H,1-9,19H2,(H2,20,27)(H,24,28)(H,25,29)(H,31,32)(H4,21,22,23)/t10-,11-,12-/m0/s1
SMILES Code: NCC(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 456.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Dutta RC, Puri A, Anand N. Immunomodulatory potential of hydrophobic analogs of Rigin and their role in providing protection against Plasmodium berghei infection in mice. Int Immunopharmacol. 2001 May;1(5):843-55. doi: 10.1016/s1567-5769(01)00021-2. PMID: 11379040.
2. Veretennikova NI, Chipens GI, Nikiforovich GV, Betinsh YR. Rigin, another phagocytosis-stimulating tetrapeptide isolated from human IgG. Confirmations of a hypothesis. Int J Pept Protein Res. 1981 Apr;17(4):430-5. doi: 10.1111/j.1399-3011.1981.tb02011.x. PMID: 7309346.