WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H575965
CAS#: 127471-94-7
Description: Isotretinoin anisatilis an orally active retinoic acid derivative for the treatment of severe refractory nodulocystic acne. It acts primarily by reducing sebaceous gland size and sebum production, and as a result alters skin surface lipid composition.
Hodoodo Cat#: H575965
Name: Isotretinoin anisatil
CAS#: 127471-94-7
Chemical Formula: C29H36O4
Exact Mass: 448.26
Molecular Weight: 448.600
Elemental Analysis: C, 77.65; H, 8.09; O, 14.27
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Synonym: GR 116526X; GR116526X; GR-116526X; Hydroxyanasatil retinoate; Isotretinoin anisatil; MDI 403; MDI403; MDI-403
IUPAC/Chemical Name: 2-(4-methoxyphenyl)-2-oxoethyl (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate
InChi Key: YDBCQZCJDPGBBE-BVYOMHTDSA-N
InChi Code: InChI=1S/C29H36O4/c1-21(12-17-26-23(3)11-8-18-29(26,4)5)9-7-10-22(2)19-28(31)33-20-27(30)24-13-15-25(32-6)16-14-24/h7,9-10,12-17,19H,8,11,18,20H2,1-6H3/b10-7+,17-12+,21-9+,22-19-
SMILES Code: COc1ccc(cc1)C(=O)COC(=O)\C=C(\C)/C=C/C=C(\C)/C=C/C2=C(C)CCCC2(C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 448.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Khalil NY, Darwish IA, Al-Qahtani AA. Isotretinoin. Profiles Drug Subst Excip Relat Methodol. 2020;45:119-157. doi: 10.1016/bs.podrm.2019.10.005. Epub 2019 Dec 6. PMID: 32164966.
2. Huang YC, Cheng YC. Isotretinoin treatment for acne and risk of depression: A systematic review and meta-analysis. J Am Acad Dermatol. 2017 Jun;76(6):1068-1076.e9. doi: 10.1016/j.jaad.2016.12.028. Epub 2017 Mar 11. Erratum in: J Am Acad Dermatol. 2017 Nov 14;: PMID: 28291553.
3. Tan TH, Hallett R, Yesudian PD. Efficacy and relapse rates of different Isotretinoin dosages in treating acne vulgaris: systemic review. Clin Med (Lond). 2016 Jun 1;16 Suppl 3(Suppl 3):s34. doi: 10.7861/clinmedicine.16-3-s34. PMID: 27252338; PMCID: PMC4989953.
