WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H464062
CAS#: 6982-09-8
Description: Sphingosine (d16:1) is an atypical sphingolipid formed by a series of enzymatic steps beginning with the condensation of myristoyl-CoA and serine via serine palmitoyltransferase long-chain base subunit 3 (SPTLC3), an SPT subunit that prefers myristoyl-CoA over palmitoyl-CoA. Sphingosine d16:1 is present in its free form at low levels in human plasma and as the sphingoid base in a variety of plasma sphingolipid species, including sphingosine-1-phosphate, ceramides, and sphingomyelins, as well as brain cerebrosides, at lower levels compared with the typical d18:1 sphingoid base. Sphingosine (d16:1) inhibits PKC in a mixed micelle activity assay. It reduces the production of superoxide induced by phorbol 12-myristate 13-acetate in isolated human neutrophils and reduces the growth of CHO cells (IC50s = 1 and 3.2 µM, respectively). Plasma levels of sphingolipids containing sphingosine (d16:1) are associated with dietary intake of saturated fatty acids and protein in ethnic Chinese individuals. Plasma levels of sphingolipids containing sphingosine (d16:1) are decreased in patients with type 2 diabetes.
Hodoodo Cat#: H464062
Name: Sphingosine (d16:1)
CAS#: 6982-09-8
Chemical Formula: C16H33NO2
Exact Mass: 271.25
Molecular Weight: 271.450
Elemental Analysis: C, 70.80; H, 12.25; N, 5.16; O, 11.79
Synonym: Sphingosine (d16:1); Sphingosine-(d16:1); D-erythro-Sphingosine C-16; D-erythro-Sphingosine C16; D-erythro-Sphingosine C 16;
IUPAC/Chemical Name: (2S,3R,E)-2-aminohexadec-4-ene-1,3-diol
InChi Key: BTUSGZZCQZACPT-YYZTVXDQSA-N
InChi Code: InChI=1S/C16H33NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-16(19)15(17)14-18/h12-13,15-16,18-19H,2-11,14,17H2,1H3/b13-12+/t15-,16+/m0/s1
SMILES Code: OC[C@@H]([C@@H](/C=C/CCCCCCCCCCC)O)N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO and DMF
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | Sphingosine (d16:1) inhibits PKC in a mixed micelle activity assay. It reduces the production of superoxide induced by phorbol 12-myristate 13-acetate (PMA) in isolated human neutrophils and reduces the growth of CHO cells (IC50s = 1 and 3.2 µM, respectively). |
| In vitro activity: | To be determined |
| In vivo activity: | To be determined |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| Soluble in DMSO | 0.0 | 100.00 |
The following data is based on the product molecular weight 271.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | To be determined |
| In vitro protocol: | To be determined |
| In vivo protocol: | To be determined |
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