WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H464121
CAS#: 2162120-87-6
Description: VH 032 amide-alkylC5-acid is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development. It incorporates an E3 ligase ligand plus alkylC5 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. It is part of a range of functionalized tool molecules for PROTAC R&D.
Hodoodo Cat#: H464121
Name: VH 032 amide-alkylC5-acid
CAS#: 2162120-87-6
Chemical Formula: C29H40N4O6S
Exact Mass: 572.27
Molecular Weight: 572.721
Elemental Analysis: C, 60.82; H, 7.04; N, 9.78; O, 16.76; S, 5.60
Synonym: VH 032 amide-alkylC5-acid; VH 032 amide alkylC5-acid; VH 032 amide-alkylC5 acid; VH 032 amide alkylC5 acid;
IUPAC/Chemical Name: 7-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptanoic acid
InChi Key: LYAMSRXTXVKKIC-TVZXLZGTSA-N
InChi Code: InChI=1S/C29H40N4O6S/c1-18-25(40-17-31-18)20-12-10-19(11-13-20)15-30-27(38)22-14-21(34)16-33(22)28(39)26(29(2,3)4)32-23(35)8-6-5-7-9-24(36)37/h10-13,17,21-22,26,34H,5-9,14-16H2,1-4H3,(H,30,38)(H,32,35)(H,36,37)/t21-,22+,26-/m1/s1
SMILES Code: CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCCCC(O)=O)=O)C(C)(C)C)=O)=O)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
Soluble in DMSO | 0.0 | 100.00 |
The following data is based on the product molecular weight 572.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |