WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H576128
CAS#: 61129-30-4
Description: Zimeldine hydrochloride hydrate is a serotonin uptake inhibitor that was formerly used for depression but was withdrawn worldwide in September 1983 because of the risk of Guillain-Barre Syndrome associated with its use.
Hodoodo Cat#: H576128
Name: Zimeldine hydrochloride hydrate
CAS#: 61129-30-4
Chemical Formula: C16H21BrCl2N2O
Exact Mass: 406.02
Molecular Weight: 408.160
Elemental Analysis: C, 47.08; H, 5.19; Br, 19.58; Cl, 17.37; N, 6.86; O, 3.92
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Synonym: H 102/09 hydrochloride monohydrate; Zimeldine hydrochloride hydrate; Zimeldine HCl hydrate
IUPAC/Chemical Name: 2-Propen-1-amine, 3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-, (Z)-, dihydrochloride monohydrate
InChi Key: WFUAVXYXJOQWAZ-GVKRCPFFSA-N
InChi Code: InChI=1S/C16H17BrN2.2ClH.H2O/c1-19(2)11-9-16(14-4-3-10-18-12-14)13-5-7-15(17)8-6-13;;;/h3-10,12H,11H2,1-2H3;2*1H;1H2/b16-9-;;;
SMILES Code: O.Cl.Cl.CN(C)C\C=C(\c1ccc(Br)cc1)/c2cccnc2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
Soluble in DMSO | 0.0 | 100.00 |
The following data is based on the product molecular weight 408.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Seppälä T, Linnoila M. Effects of zimeldine and other antidepressants on skilled performance: a comprehensive review. Acta Psychiatr Scand Suppl. 1983;308:135-40. doi: 10.1111/j.1600-0447.1983.tb11114.x. PMID: 6230887.