Nicotinyl alcohol tartrate

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H413457

CAS#: 6164-87-0

Description: Nicotinyl alcohol tartrate is a niacin derivative used as a hypolipidemic agent and as a vasodilator. It causes flushing and may decrease blood pressure. It appears as a crystal that dissolves in water and alcohol with ease, also soluble in ether; melting range 147–148 ºC.

Chemical Structure

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Nicotinyl alcohol tartrate
CAS# 6164-87-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H413457
Name: Nicotinyl alcohol tartrate
CAS#: 6164-87-0
Chemical Formula: C10H13NO7
Exact Mass: 259.07
Molecular Weight: 259.210
Elemental Analysis: C, 46.34; H, 5.06; N, 5.40; O, 43.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Nicotinyl alcohol tartrate; NSC147492; NSC-147492; NSC 147492

IUPAC/Chemical Name: pyridin-3-ylmethanol (2R,3R)-2,3-dihydroxysuccinate

InChi Key: NPORIZAYKBQYLF-LREBCSMRSA-N

InChi Code: InChI=1S/C6H7NO.C4H6O6/c8-5-6-2-1-3-7-4-6;5-1(3(7)8)2(6)4(9)10/h1-4,8H,5H2;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1

SMILES Code: OCc1cnccc1.O[C@@H](C(O)=O)[C@H](C(O)=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: to be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
To be determined 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 259.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: GILLHESPY RO. Nicotinyl alcohol tartrate in intermittent claudication. Br Med J. 1957 Jan 26;1(5012):207-8. doi: 10.1136/bmj.1.5012.207. PMID: 13383231; PMCID: PMC1974214.

2: Dujovne CA, Azarnoff DL, Pentikainen P, Manion CV, Hurwitz A. A comparative trial of clofibrate and nicotinyl alcohol tartrate in hyperlipoproteinemic patients. Am J Med Sci. 1979 May-Jun;277(3):255-61. doi: 10.1097/00000441-197905000-00002. PMID: 222145.

3: Winsor T. Thermography for studying nicotinyl alcohol tartrate. Angiology. 1975 Feb;26(2):225-32. doi: 10.1177/000331977502600206. PMID: 1090219.

4: NORWOOD WF. VASODILATOR EFFECTS OF NICOTINYL TARTRATE (RONIACOL TARTRATE). JAMA. 1963 Dec 14;186:1013. PMID: 14066712.

5: Alton C, Kowalski C, Mallon J, Marschhaus C. Observations on the cholesterol- lowering mechanism of nicotinic acid and nicotinyl alcohol tartrate. J Atheroscler Res. 1968 Mar-Apr;8(2):265-76. doi: 10.1016/s0368-1319(68)80062-6. PMID: 5664196.

6: BRANDMAN O, REDISCH W. Nicotinic alcohol tartrate (roniacol tartrate) in the treatment of peripheral vascular disease; report of 3 cases. J Med Soc N J. 1950 Jun;47(6):267-9. PMID: 15422301.

7: Badawy AA, Evans M. The effects of acute and chronic nicotine hydrogen (+)-tartrate administration and subsequent withdrawal on rat liver tryptophan pyrrolase activity and their comparison with those of morphine, phenobarbitone and ethanol. Biochem J. 1975 Jun;148(3):425-32. doi: 10.1042/bj1480425. PMID: 989; PMCID: PMC1165559.

8: Lange DE, Lübbert H, Omid A. Uber die Beeinflussung der gingivalen Entzündung durch Wirkstoffzusätze in Zahnpasten [Management of gingival inflammation with active ingredients in toothpaste]. Dtsch Zahnarztl Z. 1975 Jun;30(6):382-4. German. PMID: 1056849.

9: Kala H, Danz R, Bekemeier H, Moldenhauer H. In-vivo-Testung einer 3-Hydroxymethylpyridinhydrogentartrat-Matrixtablette. 2. Mitteilung: Vergleich der Wirkstoffliberation aus der Matrixform in vivo mit Radecol-Tabletten [In vivo testing of a 3-hydroxymethylpyridine hydrogen tartrate matrix tablet. Part 2: Comparison between the in vivo drug release from the matrix form and that from Radecol-tablets (author's transl)]. Pharmazie. 1980;35(4):216-21. German. PMID: 7403243.

10: PHILPOTT OS, WOODBURNE AR, PHILPOTT JA Jr. Roniacol tartrate in the treatment of dermatitis herpetiformis. J Invest Dermatol. 1952 Feb;18(2):87-8. doi: 10.1038/jid.1952.10. PMID: 14908182.