WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H576223
CAS#: 1130-23-0
Description: Cyclobutyrol sodium salt is a choleretic agent which also inhibits biliary lipid secretion.
Hodoodo Cat#: H576223
Name: Cyclobutyrol sodium salt
CAS#: 1130-23-0
Chemical Formula: C10H17NaO3
Exact Mass: 208.11
Molecular Weight: 208.230
Elemental Analysis: C, 57.68; H, 8.23; Na, 11.04; O, 23.05
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Synonym: Cyclobutyrol natrium; Cyclobutyrol sodium salt; Epa-Bon; Hebucol; Tri-Bil
IUPAC/Chemical Name: sodium 2-(1-hydroxycyclohexyl)butanoate
InChi Key: ZIKJCAPMXXTMDD-UHFFFAOYSA-M
InChi Code: InChI=1S/C10H18O3.Na/c1-2-8(9(11)12)10(13)6-4-3-5-7-10;/h8,13H,2-7H2,1H3,(H,11,12);/q;+1/p-1
SMILES Code: [Na+].CCC(C(=O)[O-])C1(O)CCCCC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 208.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Monte MJ, Parslow RA, Coleman R. Inhibitory action of cyclobutyrol on the secretion of biliary cholesterol and phospholipids. Biochem J. 1990 Feb 15;266(1):165-71. PubMed PMID: 2310370; PubMed Central PMCID: PMC1131110.
2: Monte MJ, Aybar R, Cava F, Esteller A, Jimenez R. Choleretic mechanism and effects of cyclobutyrol in the rat: dose-response relationship. Biomed Biochim Acta. 1990;49(1):83-90. PubMed PMID: 2360911.
3: Monte MJ, Cava F, Esteller A, Jimenez R. Inhibition of biliary cholesterol and phospholipid secretion during cyclobutyrol-induced hydrocholeresis. Biochem J. 1989 Oct 15;263(2):513-8. PubMed PMID: 2574569; PubMed Central PMCID: PMC1133458.
4: BLANC B, BLANC-CUTTOLI P. [A NEW MEDICATION FOR DIGESTIVE DISORDERS OF HEPATO-BILIARY ORIGIN: COMBINATION OF SODIUM CYCLOBUTYROL, SORBITOL AND ATROPINE SULFATE]. J Med Lyon. 1964 Oct 5;45:1679-89. French. PubMed PMID: 14205635.
5: NISHIMURA M, NAKAMATA T, SATO J, NAKAYAMA K. [On the bile-flow increasing action of the new cholagogue Lipotrin. Study of clinical trial results]. Chiryo. 1963 Aug;45:1473-80. Japanese. PubMed PMID: 13938784.