WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H413639
CAS#: 114752-42-0
Description: Dextronatrin is a potent atrial natriuretic peptide analog
Hodoodo Cat#: H413639
Name: Dextronatrin
CAS#: 114752-42-0
Chemical Formula: C110H166N34O32S2
Exact Mass: 2,539.18
Molecular Weight: 2,540.860
Elemental Analysis: C, 52.00; H, 6.59; N, 18.74; O, 20.15; S, 2.52
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Synonym: Dextronatrin; 2-D-Tyrosine-2-24-atrial natriuretic peptide-24 (rat)
IUPAC/Chemical Name: (2S,5S,8S,11S,14S,17R,23S,29S,32S,35S,41S,44S,47S)-47-((2S,5S,14S,17R,20R)-20-amino-14-benzyl-2-((S)-sec-butyl)-5-(3-guanidinopropyl)-21-(4-hydroxyphenyl)-17-(mercaptomethyl)-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazahenicosanamido)-14-(2-amino-2-oxoethyl)-32-(3-amino-3-oxopropyl)-8-benzyl-41-((S)-sec-butyl)-5,44-bis(3-guanidinopropyl)-2-(4-hydroxybenzyl)-11,29-bis(hydroxymethyl)-23-isobutyl-17-(mercaptomethyl)-35-methyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46-pentadecaoxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45-pentadecaazanonatetracontanedioic acid
InChi Key: PHMJESQTBHPHMY-POMMFSKGSA-N
InChi Code: InChI=1S/C110H166N34O32S2/c1-8-56(5)88(143-98(166)68(25-18-38-122-110(118)119)134-101(169)74(45-87(156)157)138-106(174)89(57(6)9-2)144-97(165)66(23-16-36-120-108(114)115)129-84(153)47-123-82(151)46-124-93(161)71(41-59-19-12-10-13-20-59)135-104(172)79(54-178)142-91(159)65(111)40-61-26-30-63(147)31-27-61)105(173)127-48-83(152)128-58(7)90(158)132-69(34-35-80(112)149)96(164)140-76(51-145)94(162)126-49-85(154)130-70(39-55(3)4)92(160)125-50-86(155)131-78(53-177)103(171)137-73(44-81(113)150)100(168)141-77(52-146)102(170)136-72(42-60-21-14-11-15-22-60)99(167)133-67(24-17-37-121-109(116)117)95(163)139-75(107(175)176)43-62-28-32-64(148)33-29-62/h10-15,19-22,26-33,55-58,65-79,88-89,145-148,177-178H,8-9,16-18,23-25,34-54,111H2,1-7H3,(H2,112,149)(H2,113,150)(H,123,151)(H,124,161)(H,125,160)(H,126,162)(H,127,173)(H,128,152)(H,129,153)(H,130,154)(H,131,155)(H,132,158)(H,133,167)(H,134,169)(H,135,172)(H,136,170)(H,137,171)(H,138,174)(H,139,163)(H,140,164)(H,141,168)(H,142,159)(H,143,166)(H,144,165)(H,156,157)(H,175,176)(H4,114,115,120)(H4,116,117,121)(H4,118,119,122)/t56-,57-,58-,65+,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,88-,89-/m0/s1
SMILES Code: CC[C@@H]([C@@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)Cc1ccc(O)cc1)=O)CCCNC(N)=N)=O)Cc2ccccc2)=O)CO)=O)CC(N)=O)=O)CS)=O)=O)CC(C)C)=O)=O)CO)=O)CCC(N)=O)=O)C)=O)=O)NC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)NC([C@@H](NC(CNC(CNC([C@@H](NC([C@@H](NC([C@@H](Cc3ccc(O)cc3)N)=O)CS)=O)Cc4ccccc4)=O)=O)=O)CCCNC(N)=N)=O)=O)CC(O)=O)=O)CCCNC(N)=N)=O)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 2,540.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Flückiger JP, Deghenghi R, Waeber B, Immer HU, Nussberger J, Brunner HR. Effects of dextronatrin on blood pressure, hematocrit, urinary sodium excretion and sympathetic nerve activity of rats. Fundam Clin Pharmacol. 1990;4(2):129-39. doi: 10.1111/j.1472-8206.1990.tb00480.x. PMID: 2140999.
