WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H576335
CAS#: 75690-41-4
Description: HOE402 HCl is a biochemical with hypolipidemic activity.
Hodoodo Cat#: H576335
Name: HOE402 HCl
CAS#: 75690-41-4
Chemical Formula: C17H18ClF3N6O2
Exact Mass: 430.11
Molecular Weight: 430.820
Elemental Analysis: C, 47.40; H, 4.21; Cl, 8.23; F, 13.23; N, 19.51; O, 7.43
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Synonym: HOE 402 HCl; HOE-402 HCl; HOE402 HCl; HOE402 hydrochloride
IUPAC/Chemical Name: 5-Pyrimidinecarboxamide, 4-amino-2-(4,4-dimethyl-2-oxo-1-imidazolidinyl)-N-(3-(trifluoromethyl)phenyl)-, monohydrochloride
InChi Key: MXNQOXJLUJUCGE-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H17F3N6O2.ClH/c1-16(2)8-26(15(28)25-16)14-22-7-11(12(21)24-14)13(27)23-10-5-3-4-9(6-10)17(18,19)20;/h3-7H,8H2,1-2H3,(H,23,27)(H,25,28)(H2,21,22,24);1H
SMILES Code: Cl.CC1(C)CN(C(=O)N1)c2ncc(C(=O)Nc3cccc(c3)C(F)(F)F)c(N)n2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 430.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Huettinger M, Hermann M, Goldenberg H, Granzer E, Leineweber M. Hypolipidemic activity of HOE-402 is mediated by stimulation of the LDL receptor pathway. Arterioscler Thromb. 1993 Jul;13(7):1005-12. doi: 10.1161/01.atv.13.7.1005. PMID: 8318502.