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Ronidazole
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H464378

CAS#: 7681-76-7

Description: Ronidazole is an antiprotozoal agent used in veterinary medicine for the treatment of histomoniasis and swine dysentery. It may also have use for the treatment of Tritrichomonas foetus infection in cats.

Chemical Structure

Ronidazole

CAS# 7681-76-7

Instruction

Theoretical Analysis

Hodoodo Cat#: H464378
Name: Ronidazole
CAS#: 7681-76-7
Chemical Formula: C6H8N4O4
Exact Mass: 200.05
Molecular Weight: 200.150
Elemental Analysis: C, 36.01; H, 4.03; N, 27.99; O, 31.97

Price and Availability

Size	Price	Availability
10mg	USD -2	2 Weeks
25mg	USD -2	2 Weeks
50mg	USD -2	2 Weeks
100mg	USD -2	2 Weeks
200mg	USD -2	2 Weeks
500mg	USD -2	2 Weeks
1g	USD -2	2 Weeks
2g	USD -2	2 Weeks
5g	USD 200	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Ronidazole; Ridazole; Dugro; Ridzol; Ronidazol;

IUPAC/Chemical Name: (1-methyl-5-nitro-1H-imidazol-2-yl)methyl carbamate

InChi Key: PQFRTXSWDXZRRS-UHFFFAOYSA-N

InChi Code: InChI=1S/C6H8N4O4/c1-9-4(3-14-6(7)11)8-2-5(9)10(12)13/h2H,3H2,1H3,(H2,7,11)

SMILES Code: Cn1c([N+]([O-])=O)cnc1COC(N)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO and DMF

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	MeOH	50.0	0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 200.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: AbdelKhalek A, Seleem MN. Repurposing the Veterinary Antiprotozoal Drug Ronidazole for the Treatment of Clostridioides difficile Infection. Int J Antimicrob Agents. 2020 Dec;56(6):106188. doi: 10.1016/j.ijantimicag.2020.106188. Epub 2020 Oct 9. PMID: 33045352; PMCID: PMC7704610.

2: Leelanupat A, Kamyingkird K, Chimnoi W, Nimsuphan B. Prevalence of Tritrichomonas foetus infection in cats in Bangkok metropolitan area and in vitro drug sensitivity testing. Vet Parasitol Reg Stud Reports. 2020 Jul;21:100440. doi: 10.1016/j.vprsr.2020.100440. Epub 2020 Jul 23. PMID: 32862898.

3: Nie J, Yan S, Lian L, Sharma VK, Song W. Development of fluorescence surrogates to predict the ferrate(VI) oxidation of pharmaceuticals in wastewater effluents. Water Res. 2020 Oct 15;185:116256. doi: 10.1016/j.watres.2020.116256. Epub 2020 Jul 31. PMID: 32768661.

4: Reuschel M, Pantchev N, Vrhovec MG, Jung A, Gerhauser I, Sannella AR, Cacciò SM, Legler M. Occurrence and Molecular Typing of Giardia psittaci in Parakeets in Germany-A Case Study. Avian Dis. 2020 Jun;64(2):228-233. doi: 10.1637/0005-2086-64.2.228. PMID: 32550625.

5: Diniz JA, Okumura LL, Aleixo H, Gurgel A, Silva AFS. A voltammetric screening method to determine ronidazole in bovine meat. J Environ Sci Health B. 2020;55(6):583-591. doi: 10.1080/03601234.2020.1745523. Epub 2020 Apr 2. PMID: 32238102.

6: Hedgespeth BA, Stauffer SH, Robertson JB, Gookin JL. Association of fecal sample collection technique and treatment history with Tritrichomonas foetus polymerase chain reaction test results in 1717 cats. J Vet Intern Med. 2020 Mar;34(2):734-741. doi: 10.1111/jvim.15727. Epub 2020 Feb 10. PMID: 32039505; PMCID: PMC7096610.

7: Wang XZ, Mao XY, Zhang ZQ, Guo R, Zhang YY, Zhu NJ, Wang K, Sun PP, Huo JZ, Wang XR, Ding B. Solvothermal and Ultrasonic Preparation of Two Unique Cluster- Based Lu and Y Coordination Materials: Metal-Organic Framework-Based Ratiometric Fluorescent Biosensor for an Ornidazole and Ronidazole and Sensing Platform for a Biomarker of Amoeba Liver Abscess. Inorg Chem. 2020 Mar 2;59(5):2910-2922. doi: 10.1021/acs.inorgchem.9b03272. Epub 2020 Feb 10. PMID: 32037805.

8: Hinney B, Christen I, Jähne S, Gaisbauer S, Schrammel N, Markl A, Joachim A, Künzel F. Efficacy and safety of ronidazole treatment against Tritrichomonas foetus in a cat colony with multiple disorders. Vet Parasitol Reg Stud Reports. 2019 Dec;18:100344. doi: 10.1016/j.vprsr.2019.100344. Epub 2019 Nov 2. PMID: 31796193.

9: Martínez-Morcillo S, Rodríguez-Gil JL, Fernández-Rubio J, Rodríguez-Mozaz S, Míguez-Santiyán MP, Valdes ME, Barceló D, Valcárcel Y. Presence of pharmaceutical compounds, levels of biochemical biomarkers in seafood tissues and risk assessment for human health: Results from a case study in North-Western Spain. Int J Hyg Environ Health. 2020 Jan;223(1):10-21. doi: 10.1016/j.ijheh.2019.10.011. Epub 2019 Nov 6. PMID: 31706926.

10: Pandeti S, Ameixa J, Khreis JM, Feketeová L, Chirot F, Reddy TJ, Abdoul- Carime H, Ferreira da Silva F, Denifl S, O'Hair RAJ, Farizon B, Farizon M, Märk TD. Decomposition of protonated ronidazole studied by low-energy and high-energy collision-induced dissociation and density functional theory. J Chem Phys. 2019 Oct 28;151(16):164306. doi: 10.1063/1.5118844. PMID: 31675859.

11: Dickson R, Vose J, Bemis D, Daves M, Cecere T, Gookin JL, Steiner J, Tolbert MK. The effect of enterococci on feline Tritrichomonas foetus infection in vitro. Vet Parasitol. 2019 Sep;273:90-96. doi: 10.1016/j.vetpar.2019.08.012. Epub 2019 Aug 20. PMID: 31454711.

12: Si F, Zhang Y, Yao C, Du M, Hussain I, Huang S, Wen W, Hu X. Degradation of ronidazole by electrochemically simultaneously generated persulfate and ferrous ions. Chemosphere. 2020 Jan;238:124579. doi: 10.1016/j.chemosphere.2019.124579. Epub 2019 Aug 12. PMID: 31434045.

13: Wei JH, Yi JW, Han ML, Li B, Liu S, Wu YP, Ma LF, Li DS. A Water-Stable Terbium(III)-Organic Framework as a Chemosensor for Inorganic Ions, Nitro- Containing Compounds and Antibiotics in Aqueous Solutions. Chem Asian J. 2019 Oct 15;14(20):3694-3701. doi: 10.1002/asia.201900706. Epub 2019 Aug 5. PMID: 31347761.

14: Li JM, Huo R, Li X, Sun HL. Lanthanide-Organic Frameworks Constructed from 2,7-Naphthalenedisulfonate and 1H-Imidazo[4,5-f][1,10]-phenanthroline: Synthesis, Structure, and Luminescence with Near-Visible Light Excitation and Magnetic Properties. Inorg Chem. 2019 Aug 5;58(15):9855-9865. doi: 10.1021/acs.inorgchem.9b00925. Epub 2019 Jul 23. PMID: 31335124.

15: Zou XY, Lin YL, Xu B, Zhang TY, Hu CY, Cao TC, Chu WH, Pan Y, Gao NY. Enhanced ronidazole degradation by UV-LED/chlorine compared with conventional low-pressure UV/chlorine at neutral and alkaline pH values. Water Res. 2019 Sep 1;160:296-303. doi: 10.1016/j.watres.2019.05.072. Epub 2019 May 23. PMID: 31154127.

16: Pandeti S, Feketeová L, Reddy TJ, Abdoul-Carime H, Farizon B, Farizon M, Märk TD. Binding preference of nitroimidazolic radiosensitizers to nucleobases and nucleosides probed by electrospray ionization mass spectrometry and density functional theory. J Chem Phys. 2019 Jan 7;150(1):014302. doi: 10.1063/1.5062604. PMID: 30621427.

17: Yang W , Wu X , Liu T , Wang T , Hou X . A triazine-based conjugated microporous polymer composite for magnetic solid phase extraction of 5-nitroimidazoles coupled with UPLC-MS/MS for quantification. Analyst. 2018 Nov 19;143(23):5744-5753. doi: 10.1039/c8an01600c. PMID: 30325370.

18: Bastos BF, Brener B, de Figueiredo MA, Leles D, Mendes-de-Almeida F. Pentatrichomonas hominis infection in two domestic cats with chronic diarrhea. JFMS Open Rep. 2018 May 30;4(1):2055116918774959. doi: 10.1177/2055116918774959. PMID: 29872537; PMCID: PMC5977435.

19: Sakai T, Nemoto S, Teshima R, Akiyama H. [Analytical Method for Nitroimidazoles and Their Major Metabolites in Livestock and Fishery Products Using LC-MS/MS]. Shokuhin Eiseigaku Zasshi. 2017;58(4):180-187. Japanese. doi: 10.3358/shokueishi.58.180. PMID: 28855472.

20: Tuzimski T, Rejczak T. A QuEChERS-Based Sample Preparation Method for the Analysis of 5-Nitroimidazoles in Bovine Milk by HPLC-DAD. J AOAC Int. 2017 Nov 1;100(6):1671-1680. doi: 10.5740/jaoacint.17-0213. Epub 2017 Jul 13. PMID: 28707620.

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Ronidazole featured