WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H464501
CAS#: 2107-76-8
Description: NSC 5302 is a synthetic coumarin with diverse biological activities. It scavenges alkylperoxy radicals and hypochlorous acid (HOCl; IC50 = 2.85 µM) in cell-free assays, as well as inhibits lipid peroxidation in rat liver microsomes, A23187-induced thromboxane B2 (TXB2) generation in isolated rat peritoneal leukocytes, and myeloperoxidase (MPO) activity in a cell-free assay (IC50s = 12, 1, and 1.06 µM, respectively). NSC 5302 also inhibits rat lens aldose reductase (IC50 = 17 µM) and human carbonic anhydrase I (CAI), CAIX, and CAXII with Ki values of 8.4, 0.19, and 6.4 µM, respectively. It inhibits platelet aggregation induced by arachidonic acid with an IC50 value of 45 µM. NSC 5302 inhibits hepatitis C virus (HCV) non-structural protein 5B (NS5B) polymerase (IC50 = 47.2 µM). It is active against H. pylori with an MIC value of 10 µg/ml.
Hodoodo Cat#: H464501
Name: NSC 5302
CAS#: 2107-76-8
Chemical Formula: C10H8O4
Exact Mass: 192.04
Molecular Weight: 192.170
Elemental Analysis: C, 62.50; H, 4.20; O, 33.30
Synonym: NSC 5302; NSC-5302; NSC5302; 5,7-Dihydroxy-4-methylcoumarin;
IUPAC/Chemical Name: 5,7-dihydroxy-4-methyl-2H-chromen-2-one
InChi Key: QNVWGEJMXOQQPM-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H8O4/c1-5-2-9(13)14-8-4-6(11)3-7(12)10(5)8/h2-4,11-12H,1H3
SMILES Code: O=C1OC2=C(C(O)=CC(O)=C2)C(C)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 30.0 | 156.00 | |
| DMSO | 30.0 | 156.00 | |
| DMSO:PBS (pH 7.2) (1:3) | 0.3 | 1.30 | |
| Ethanol | 20.0 | 104.00 |
The following data is based on the product molecular weight 192.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
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