RJN00281

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H464656

CAS#: unknown

Description: RJN00281 is a novel anti-Parkinson agent, targeting the D2R. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to Hodoodo Chemical Nomenclature (https://www.hodoodo.com/page/naming).

Chemical Structure

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RJN00281
CAS# unknown
Instruction

Theoretical Analysis

Hodoodo Cat#: H464656
Name: RJN00281
CAS#: unknown
Chemical Formula: C13H19N3O4
Exact Mass: 281.14
Molecular Weight: 281.312
Elemental Analysis: C, 55.51; H, 6.81; N, 14.94; O, 22.75

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: RJN00281; RJN 00281; RJN-00281; 3-Furoyl-L-leucylglycinamide;

IUPAC/Chemical Name: (S)-N-(1-((2-amino-2-oxoethyl)amino)-4-methyl-1-oxopentan-2-yl)furan-3-carboxamide

InChi Key: RYAUDQTUUTVOSS-JTQLQIEISA-N

InChi Code: InChI=1S/C13H19N3O4/c1-8(2)5-10(13(19)15-6-11(14)17)16-12(18)9-3-4-20-7-9/h3-4,7-8,10H,5-6H2,1-2H3,(H2,14,17)(H,15,19)(H,16,18)/t10-/m0/s1

SMILES Code: O=C(NCC(N)=O)[C@H](CC(C)C)NC(C1=COC=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 281.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sampaio-Dias IE, Reis-Mendes A, Costa VM, García-Mera X, Brea J, Loza MI, Pires-Lima BL, Alcoholado C, Algarra M, Rodríguez-Borges JE. Discovery of New Potent Positive Allosteric Modulators of Dopamine D2 Receptors: Insights into the Bioisosteric Replacement of Proline to 3-Furoic Acid in the Melanostatin Neuropeptide. J Med Chem. 2021 Apr 16. doi: 10.1021/acs.jmedchem.1c00252. Epub ahead of print. PMID: 33861612.