WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H464681
CAS#: 1184991-14-7
Description: Clofibric acid-d4 is intended for use as an internal standard for the quantification of clofibric acid by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 µM in a transactivation assay) and the active metabolite of clofibrate. It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (C. carpio) when administered in tank water at a concentration of 10 µg/L. Clofibric acid has been found in wastewater effluent.
Hodoodo Cat#: H464681
Name: Clofibric Acid-d4
CAS#: 1184991-14-7
Chemical Formula: C10H7D4ClO3
Exact Mass: 218.06
Molecular Weight: 218.669
Elemental Analysis: C, 54.93; H, 6.91; Cl, 16.21; O, 21.95
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Clofibric Acid-d4; Clofibric Acid d4;
IUPAC/Chemical Name: 2-(4-chlorophenoxy-2,3,5,6-d4)-2-methylpropanoic acid
InChi Key: TXCGAZHTZHNUAI-LNFUJOGGSA-N
InChi Code: InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)/i3D,4D,5D,6D
SMILES Code: OC(C(C)(OC1=C(C([2H])=C(Cl)C([2H])=C1[2H])[2H])C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 218.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Dular M, Griessler-Bulc T, Gutierrez-Aguirre I, Heath E, Kosjek T, Krivograd Klemenčič A, Oder M, Petkovšek M, Rački N, Ravnikar M, Šarc A, Širok B, Zupanc M, Žitnik M, Kompare B. Use of hydrodynamic cavitation in (waste)water treatment. Ultrason Sonochem. 2016 Mar;29:577-88. doi: 10.1016/j.ultsonch.2015.10.010. Epub 2015 Oct 19. PMID: 26515938.
2: Francik R, Kryczyk J, Francik S. CORONARY EFFECT OF FIBRATES ON PROTEINS AND ENZYMES WHICH HYDROLYZE TRIACYLGLYCEROLS. Acta Pol Pharm. 2016 May- Jun;73(3):579-88. PMID: 27476274.
