WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H111008
CAS#: 54970-91-1
Description: 2',3'-Dialdehyde ATP is a derivative of, and the oxidized form of, ATP. It has been found to be a specific, irreversible inhibitor of component A3 of the methylreductase system which plays a role in processing amino acids.
Hodoodo Cat#: H111008
Name: 2',3'-Dialdehyde ATP
CAS#: 54970-91-1
Chemical Formula: C10H14N5O13P3
Exact Mass: 504.98
Molecular Weight: 505.165
Elemental Analysis: C, 23.78; H, 2.79; N, 13.86; O, 41.17; P, 18.39
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Synonym: Adenosine 5'-triphosphate; 2',3',-dialdehyde ATP Dialdehyde; Dial-ATP; oATP; OATP (oxidized adenosine triphosphate); Oxidized ATP; Oxo-ATP
IUPAC/Chemical Name: P-(2-(1-(6-amino-9H-purin-9-yl)-2-oxoethoxy-3-oxopropyl)) ester
InChi Key: ZOSTZYMLOPBGQI-NKWVEPMBSA-N
InChi Code: InChI=1S/C10H14N5O13P3/c11-9-8-10(13-4-12-9)15(5-14-8)7(2-17)26-6(1-16)3-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,4-7H,3H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t6-,7+/m0/s1
SMILES Code: Nc1ncnc2c1ncn2[C@H](O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C=O)C=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 505.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Chen HB, Lin YH, Sun SH. Oxidized ATP decreases beta-actin expression and intracellular superoxide concentrations in RBA-2 type-2 astrocytes independently of P2X7 receptor. Eur J Pharmacol. 2006 Nov 21;550(1-3):1-7. doi: 10.1016/j.ejphar.2006.08.039. Epub 2006 Sep 5. PMID: 17020759.
2. Wu PY, Lin YC, Chang CL, Lu HT, Chin CH, Hsu TT, Chu D, Sun SH. Functional decreases in P2X7 receptors are associated with retinoic acid-induced neuronal differentiation of Neuro-2a neuroblastoma cells. Cell Signal. 2009 Jun;21(6):881-91. doi: 10.1016/j.cellsig.2009.01.036. PMID: 19385050.
3. Lang PA, Merkler D, Funkner P, Shaabani N, Meryk A, Krings C, Barthuber C, Recher M, Brück W, Häussinger D, Ohashi PS, Lang KS. Oxidized ATP inhibits T-cell-mediated autoimmunity. Eur J Immunol. 2010 Sep;40(9):2401-8. doi: 10.1002/eji.200939838. PMID: 20683833.
4. Schachter J, Valadao AL, Aguiar RS, Barreto-de-Souza V, Rossi AD, Arantes PR, Verli H, Quintana PG, Heise N, Tanuri A, Bou-Habib DC, Persechini PM. 2´,3´-Dialdehyde of ATP, ADP, and adenosine inhibit HIV-1 reverse transcriptase and HIV-1 replication. Curr HIV Res. 2014;12(5):347-58. doi: 10.2174/1570162x12666140826105824. PMID: 25174839.