WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H464723
CAS#: 86293-40-5
Description: Methylaervine is a natural antifungal agent, significantly inducing lipid peroxidation, activating the antioxidant enzymes, and exhibiting effective activity against F. solani (EC50 = 10.56 µM).
Hodoodo Cat#: H464723
Name: Methylaervine
CAS#: 86293-40-5
Chemical Formula: C15H10N2O2
Exact Mass: 250.07
Molecular Weight: 250.257
Elemental Analysis: C, 71.99; H, 4.03; N, 11.19; O, 12.79
This product is not in stock, which may be available by custom synthesis.
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Synonym: Methylaervine; NSC-341584; NSC341584; NSC 341584; 10-methoxycanthine-6-one;
IUPAC/Chemical Name: 10-methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one
InChi Key: FDBMONUDUKGKGY-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H10N2O2/c1-19-9-2-4-13-11(8-9)10-6-7-16-12-3-5-14(18)17(13)15(10)12/h2-8H,1H3
SMILES Code: O=C1N2C3=C(N=CC=C3C4=C2C=CC(OC)=C4)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 250.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Dan W, Gao J, Li L, Xu Y, Wang J, Dai J. Cellular and non-target metabolomics approaches to understand the antifungal activity of methylaervine against Fusarium solani. Bioorg Med Chem Lett. 2021 Apr 26;43:128068. doi: 10.1016/j.bmcl.2021.128068. Epub ahead of print. PMID: 33915256.
2: Bharitkar YP, Hazra A, Apoorva Poduri NS, Ash A, Maulik PR, Mondal NB. Isolation, structural elucidation and cytotoxicity evaluation of a new pentahydroxy-pimarane diterpenoid along with other chemical constituents from Aerva lanata. Nat Prod Res. 2015 Feb;29(3):253-61. doi: 10.1080/14786419.2014.971794. Epub 2014 Oct 28. PMID: 25348942.
3: Goyal M, Pareek A, Nagori BP, Sasmal D. Aerva lanata: A review on phytochemistry and pharmacological aspects. Pharmacogn Rev. 2011 Jul;5(10):195-8. doi: 10.4103/0973-7847.91120. PMID: 22279378; PMCID: PMC3263055.
