WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H414250
CAS#: 17306-46-6
Description: Rhoifolin is a chemical compound. It is first isolated from plant Rhus succedanea. The term "Rhoi" derived from generic name of plant Rhus.
Hodoodo Cat#: H414250
Name: Rhoifolin
CAS#: 17306-46-6
Chemical Formula: C27H30O14
Exact Mass: 578.16
Molecular Weight: 578.520
Elemental Analysis: C, 56.06; H, 5.23; O, 38.72
Synonym: Rhoifolin; NSC649413; NSC-649413; NSC 649413
IUPAC/Chemical Name: 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
InChi Key: RPMNUQRUHXIGHK-PYXJVEIZSA-N
InChi Code: InChI=1S/C27H30O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-8,10,18,20-30,32-36H,9H2,1H3/t10-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1
SMILES Code: O=C1C2=C(O)C=C(O[C@H]3[C@H](O[C@]4([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C=C2OC(C5=CC=C(O)C=C5)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 578.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Liao S, Song F, Feng W, Ding X, Yao J, Song H, Liu Y, Ma S, Wang Z, Lin X, Xu J, Zhao J, Liu Q. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. J Cell Physiol. 2019 Aug;234(10):17600-17611. doi: 10.1002/jcp.28384. Epub 2019 Mar 10. PMID: 30854667.
2: Peng S, Hu C, Liu X, Lei L, He G, Xiong C, Wu W. Rhoifolin regulates oxidative stress and proinflammatory cytokine levels in Freund's adjuvant- induced rheumatoid arthritis via inhibition of NF-κB. Braz J Med Biol Res. 2020;53(6):e9489. doi: 10.1590/1414-431x20209489. Epub 2020 May 8. PMID: 32401927; PMCID: PMC7233197.
3: Jo S, Kim S, Shin DH, Kim MS. Inhibition of SARS-CoV 3CL protease by flavonoids. J Enzyme Inhib Med Chem. 2020 Dec;35(1):145-151. doi: 10.1080/14756366.2019.1690480. PMID: 31724441; PMCID: PMC6882434.
4: Fang J, Cao Z, Song X, Zhang X, Mai B, Wen T, Lin J, Chen J, Chi Y, Su T, Xiao F. Rhoifolin Alleviates Inflammation of Acute Inflammation Animal Models and LPS-Induced RAW264.7 Cells via IKKβ/NF-κB Signaling Pathway. Inflammation. 2020 Dec;43(6):2191-2201. doi: 10.1007/s10753-020-01286-x. PMID: 32617861.
5: Brinza I, Abd-Alkhalek AM, El-Raey MA, Boiangiu RS, Eldahshan OA, Hritcu L. Ameliorative Effects of Rhoifolin in Scopolamine-Induced Amnesic Zebrafish (Danio rerio) Model. Antioxidants (Basel). 2020 Jul 3;9(7):580. doi: 10.3390/antiox9070580. PMID: 32635149; PMCID: PMC7401873.
6: Adhikari B, Marasini BP, Rayamajhee B, Bhattarai BR, Lamichhane G, Khadayat K, Adhikari A, Khanal S, Parajuli N. Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID-19: A review. Phytother Res. 2021 Mar;35(3):1298-1312. doi: 10.1002/ptr.6893. Epub 2020 Oct 9. PMID: 33037698; PMCID: PMC7675695.
7: Liu H, Xu C, Wang W, Zhao Y. Development and Validation of an LC-ESI-MS/MS Method for Simultaneous Determination of Ligustroflavone and Rhoifolin in Rat Plasma and Its Application to a Pharmacokinetic Study. J Chromatogr Sci. 2017 Mar 1;55(3):267-274. doi: 10.1093/chromsci/bmw181. PMID: 27884870.
8: Aoki C, Takeuchi Y, Higashi K, Okamoto Y, Nakanishi A, Tandia M, Uzawa J, Ueda K, Moribe K. Structural elucidation of a novel transglycosylated compound α-glucosyl rhoifolin and of α-glucosyl rutin by NMR spectroscopy. Carbohydr Res. 2017 Apr 18;443-444:37-41. doi: 10.1016/j.carres.2017.03.011. Epub 2017 Mar 16. PMID: 28334636.
9: Rao YK, Lee MJ, Chen K, Lee YC, Wu WS, Tzeng YM. Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells. Evid Based Complement Alternat Med. 2011;2011:624375. doi: 10.1093/ecam/nep204. Epub 2011 Mar 10. PMID: 20008903; PMCID: PMC3152991.
10: Ishii K, Urano S, Furuta T, Kasuya Y. Determination of rhoifolin and daidzin in human plasma by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1994 May 13;655(2):300-4. doi: 10.1016/0378-4347(94)00115-4. PMID: 8081478.
