WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H464835
CAS#: 62480-44-8
Description: VZN-80448 is a fluorogenic substrate for leucine aminopeptidase. Upon enzymatic cleavage by leucine aminopeptidase, AMC is released and its fluorescence can be used to quantify leucine aminopeptidase activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to Hodoodo Chemical Nomenclature (https://www.hodoodo.com/page/naming).
Hodoodo Cat#: H464835
Name: VZN-80448
CAS#: 62480-44-8
Chemical Formula: C16H21ClN2O3
Exact Mass: 0.00
Molecular Weight: 324.805
Elemental Analysis: C, 59.17; H, 6.52; Cl, 10.91; N, 8.62; O, 14.78
Synonym: VZN-80448; VZN 80448; VZN80448; L-Leu-AMC HCl; L-Leu-AMC hydrochloride;
IUPAC/Chemical Name: (S)-2-amino-4-methyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)pentanamide hydrochloride
InChi Key: VCRXITKKWBOQRZ-ZOWNYOTGSA-N
InChi Code: InChI=1S/C16H20N2O3.ClH/c1-9(2)6-13(17)16(20)18-11-4-5-12-10(3)7-15(19)21-14(12)8-11;/h4-5,7-9,13H,6,17H2,1-3H3,(H,18,20);1H/t13-;/m0./s1
SMILES Code: CC(C1=CC=C(C=C1O2)NC([C@H](CC(C)C)N)=O)=CC2=O.Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMF | 25.0 | 76.97 | |
DMSO | 25.0 | 76.97 | |
DMSO:PBS (pH 7.2) (1:3) | 0.3 | 0.77 |
The following data is based on the product molecular weight 324.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Cheng T, Chepkirui C, Decock C, Matasyoh JC, Stadler M. Skeletocutins M-Q: biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa. Beilstein J Org Chem. 2019 Nov 19;15:2782-2789. doi: 10.3762/bjoc.15.270. PMID: 31807212; PMCID: PMC6880814.