WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H464882
CAS#: unknown
Description: UNC6641 is a novel peptidomimetic antagonist of the PHF1 Tudor domain, binding both PHF1 Tudor domain and the related protein PHF19.
Hodoodo Cat#: H464882
Name: UNC6641
CAS#: unknown
Chemical Formula: C49H86N14O8
Exact Mass: 998.68
Molecular Weight: 999.317
Elemental Analysis: C, 58.89; H, 8.67; N, 19.62; O, 12.81
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Synonym: UNC6641; UNC 6641; UNC-6641;
IUPAC/Chemical Name: (S)-N-((S)-1-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-1-(N6-glycylglycyl-L-valyl-N2-isopropyl-N2-phenethyl-L-lysyl-L-lysyl)pyrrolidine-2-carboxamide
InChi Key: YKOIXRDPLTWEFE-WAGJPQHASA-N
InChi Code: InChI=1S/C49H86N14O8/c1-31(2)28-37(44(67)58-35(43(52)66)19-14-25-56-49(53)54)60-46(69)39-21-15-26-63(39)48(71)36(18-10-12-23-50)59-45(68)38(62(33(5)6)27-22-34-16-8-7-9-17-34)20-11-13-24-55-47(70)42(32(3)4)61-41(65)30-57-40(64)29-51/h7-9,16-17,31-33,35-39,42H,10-15,18-30,50-51H2,1-6H3,(H2,52,66)(H,55,70)(H,57,64)(H,58,67)(H,59,68)(H,60,69)(H,61,65)(H4,53,54,56)/t35-,36-,37-,38-,39-,42-/m0/s1
SMILES Code: O=C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)[C@H](CCCCNC([C@H](C(C)C)NC(CNC(CN)=O)=O)=O)N(CCC2=CC=CC=C2)C(C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 999.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Engelberg IA, Liu J, Norris-Drouin JL, Cholensky SH, Ottavi SA, Frye SV, Kutateladze TG, James LI. Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1). J Med Chem. 2021 Jun 24;64(12):8510-8522. doi: 10.1021/acs.jmedchem.1c00430. Epub 2021 May 17. PMID: 33999620; PMCID: PMC8225578.