WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H464911
CAS#: unknown
Description: F-15741 is a selective, potent inhibitor of the late current mediated by the cardiac isoform of the sodium channel (NaV1.5).
Hodoodo Cat#: H464911
Name: F-15741
CAS#: unknown
Chemical Formula: C20H25NO2S2
Exact Mass: 375.13
Molecular Weight: 375.545
Elemental Analysis: C, 63.97; H, 6.71; N, 3.73; O, 8.52; S, 17.07
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Synonym: F-15741; F15741; F 15741;
IUPAC/Chemical Name: 2-(((S)-3-(((R)-3,4-dihydro-2H-benzo[b][1,4]oxathiepin-3-yl)amino)-2-methylpropyl)thio)-6-methylphenol
InChi Key: KHMJPCBCJWSRNL-GOEBONIOSA-N
InChi Code: InChI=1S/C20H25NO2S2/c1-14(12-24-19-9-5-6-15(2)20(19)22)10-21-16-11-23-17-7-3-4-8-18(17)25-13-16/h3-9,14,16,21-22H,10-13H2,1-2H3/t14-,16+/m0/s1
SMILES Code: C[C@H](CSC1=CC=CC(C)=C1O)CN[C@@H]2COC3=CC=CC=C3SC2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 375.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Le Grand B, Pignier C, Létienne R, Colpaert F, Cuisiat F, Rolland F, Mas A, Borras M, Vacher B. Na+ currents in cardioprotection: better to be late. J Med Chem. 2009 Jul 23;52(14):4149-60. doi: 10.1021/jm900296e. PMID: 19514733.