WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H465236
CAS#: unknown
Description: MLRI is a cationic lipid for RNA and vaccine delivery
Hodoodo Cat#: H465236
Name: MLRI
CAS#: unknown
Chemical Formula: C33H66INO5
Exact Mass: 683.40
Molecular Weight: 683.798
Elemental Analysis: C, 57.96; H, 9.73; I, 18.56; N, 2.05; O, 11.70
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Synonym: MLRI;
IUPAC/Chemical Name: 2-(dodecanoyloxy)-N-(2-hydroxyethyl)-N,N-dimethyl-3-(tetradecanoyloxy)propan-1-aminium iodide
InChi Key: ATZSPYLAVQRGFK-UHFFFAOYSA-M
InChi Code: InChI=1S/C33H66NO5.HI/c1-5-7-9-11-13-15-16-18-19-21-23-25-32(36)38-30-31(29-34(3,4)27-28-35)39-33(37)26-24-22-20-17-14-12-10-8-6-2;/h31,35H,5-30H2,1-4H3;1H/q+1;/p-1
SMILES Code: C[N+](C)(CC(COC(CCCCCCCCCCCCC)=O)OC(CCCCCCCCCCC)=O)CCO.[I-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 683.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Kalil J, Wollman EE. Role of class I and class II antigens in the allogenic stimulation: class I and class II recognition in allogenic stimulation; blocking of MLR by monoclonal antibodies and F(ab')2 fragments. Cell Immunol. 1983 Jul 15;79(2):367-73. doi: 10.1016/0008-8749(83)90078-3. PMID: 6223710.
2: Hecker JG, Hall LL, Irion VR. Nonviral gene delivery to the lateral ventricles in rat brain: initial evidence for widespread distribution and expression in the central nervous system. Mol Ther. 2001 Mar;3(3):375-84. doi: 10.1006/mthe.2001.0272. PMID: 11273780.
3: Hauck ES, Zou S, Scarfo K, Nantz MH, Hecker JG. Whole animal in vivo imaging after transient, nonviral gene delivery to the rat central nervous system. Mol Ther. 2008 Nov;16(11):1857-64. doi: 10.1038/mt.2008.183. Epub 2008 Aug 26. PMID: 18728638; PMCID: PMC2575133.