WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H465247
CAS#: unknown
Description: DSGLA is a cationic lipid for RNA and vaccine delivery.
Hodoodo Cat#: H465247
Name: DSGLA
CAS#: unknown
Chemical Formula: C46H99Cl3N6O
Exact Mass: 856.69
Molecular Weight: 858.689
Elemental Analysis: C, 64.34; H, 11.62; Cl, 12.39; N, 9.79; O, 1.86
This product is not in stock, which may be available by custom synthesis.
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Synonym: DSGLA;
IUPAC/Chemical Name: (S)-N-(2-(6-((amino(iminio)methyl)amino)-2-ammoniohexanamido)ethyl)-N-methyl-N-octadecyloctadecan-1-aminium chloride
InChi Key: ZZUYVEFGBZXOOI-DYGFFKSMSA-N
InChi Code: InChI=1S/C46H96N6O.3ClH/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-32-36-41-52(3,43-40-50-45(53)44(47)38-34-35-39-51-46(48)49)42-37-33-31-29-27-25-23-21-19-17-15-13-11-9-7-5-2;;;/h44H,4-43,47H2,1-3H3,(H4-,48,49,50,51,53);3*1H/t44-;;;/m0.../s1
SMILES Code: NC(NCCCC[C@H]([NH3+])C(NCC[N+](CCCCCCCCCCCCCCCCCC)(C)CCCCCCCCCCCCCCCCCC)=O)=[NH2+].[Cl-].[Cl-].[Cl-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 858.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Charbe NB, Amnerkar ND, Ramesh B, Tambuwala MM, Bakshi HA, Aljabali AAA, Khadse SC, Satheeshkumar R, Satija S, Metha M, Chellappan DK, Shrivastava G, Gupta G, Negi P, Dua K, Zacconi FC. Small interfering RNA for cancer treatment: overcoming hurdles in delivery. Acta Pharm Sin B. 2020 Nov;10(11):2075-2109. doi: 10.1016/j.apsb.2020.10.005. Epub 2020 Oct 13. PMID: 33304780; PMCID: PMC7714980.
2: Li SD, Huang L. Nanoparticles evading the reticuloendothelial system: role of the supported bilayer. Biochim Biophys Acta. 2009 Oct;1788(10):2259-66. doi: 10.1016/j.bbamem.2009.06.022. Epub 2009 Jul 10. PMID: 19595666; PMCID: PMC2757503.
3: Chen Y, Sen J, Bathula SR, Yang Q, Fittipaldi R, Huang L. Novel cationic lipid that delivers siRNA and enhances therapeutic effect in lung cancer cells. Mol Pharm. 2009 May-Jun;6(3):696-705. doi: 10.1021/mp800136v. PMID: 19267451; PMCID: PMC2763490.
