WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H465251
CAS#: unknown
Description: MVL5 is a lipid for RNA and vaccine delivery.
Hodoodo Cat#: H465251
Name: MVL5
CAS#: unknown
Chemical Formula: C59H111N7O4
Exact Mass: 981.87
Molecular Weight: 982.582
Elemental Analysis: C, 72.12; H, 11.39; N, 9.98; O, 6.51
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: MVL5; MVL 5; MVL-5;
IUPAC/Chemical Name: N-(2-(2-((3-aminopropyl)amino)-5-(bis(3-aminopropyl)amino)pentanamido)ethyl)-3,4-bis(((Z)-octadec-9-en-1-yl)oxy)benzamide
InChi Key: DBQMYYNZVOQICL-CLFAGFIQSA-N
InChi Code: InChI=1S/C59H111N7O4/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-51-69-56-41-40-54(53-57(56)70-52-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)58(67)64-46-47-65-59(68)55(63-45-36-42-60)39-35-48-66(49-37-43-61)50-38-44-62/h17-20,40-41,53,55,63H,3-16,21-39,42-52,60-62H2,1-2H3,(H,64,67)(H,65,68)/b19-17-,20-18-
SMILES Code: O=C(NCCNC(C(CCCN(CCCN)CCCN)NCCCN)=O)C1=CC(OCCCCCCCC/C=C\CCCCCCCC)=C(OCCCCCCCC/C=C\CCCCCCCC)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 982.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Majzoub RN, Wonder E, Ewert KK, Kotamraju VR, Teesalu T, Safinya CR. Rab11 and Lysotracker Markers Reveal Correlation between Endosomal Pathways and Transfection Efficiency of Surface-Functionalized Cationic Liposome-DNA Nanoparticles. J Phys Chem B. 2016 Jul 7;120(26):6439-53. doi: 10.1021/acs.jpcb.6b04441. Epub 2016 Jun 3. PMID: 27203598; PMCID: PMC4936928.
2: Chan CL, Ewert KK, Majzoub RN, Hwu YK, Liang KS, Leal C, Safinya CR. Optimizing cationic and neutral lipids for efficient gene delivery at high serum content. J Gene Med. 2014 Mar-Apr;16(3-4):84-96. doi: 10.1002/jgm.2762. PMID: 24753287; PMCID: PMC4051313.
3: Leal C, Ewert KK, Shirazi RS, Bouxsein NF, Safinya CR. Nanogyroids incorporating multivalent lipids: enhanced membrane charge density and pore forming ability for gene silencing. Langmuir. 2011 Jun 21;27(12):7691-7. doi: 10.1021/la200679x. Epub 2011 May 25. PMID: 21612245; PMCID: PMC3119580.
4: Zidovska A, Ewert KK, Quispe J, Carragher B, Potter CS, Safinya CR. Block Liposome and Nanotube Formation is a General Phenomenon of Two-Component Membranes Containing Multivalent Lipids. Soft Matter. 2011 Jan 1;7(18):8363-8369. doi: 10.1039/C1SM05481C. Epub 2011 Jun 20. PMID: 22707975; PMCID: PMC3374606.
5: Bouxsein NF, McAllister CS, Ewert KK, Samuel CE, Safinya CR. Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA. Biochemistry. 2007 Apr 24;46(16):4785-92. doi: 10.1021/bi062138l. Epub 2007 Mar 29. PMID: 17391006.
