WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H465426
CAS#: unknown
Description: VGD071 is a CD4 and sortilin inhibitor. It displayed activity for sortilin down-modulation and reduction of progranulin-induced breast cancer stem cell propagation.
Hodoodo Cat#: H465426
Name: VGD071
CAS#: unknown
Chemical Formula: C32H41N3O4S2
Exact Mass: 595.25
Molecular Weight: 595.817
Elemental Analysis: C, 64.51; H, 6.94; N, 7.05; O, 10.74; S, 10.76
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Synonym: VGD071; VGD 071; VGD-071;
IUPAC/Chemical Name: 3-methylene-9-phenethyl-1,5-ditosyl-1,5,9-triazacyclododecane
InChi Key: WLNGLSFIPLGHIS-UHFFFAOYSA-N
InChi Code: InChI=1S/C32H41N3O4S2/c1-27-11-15-31(16-12-27)40(36,37)34-22-7-20-33(24-19-30-9-5-4-6-10-30)21-8-23-35(26-29(3)25-34)41(38,39)32-17-13-28(2)14-18-32/h4-6,9-18H,3,7-8,19-26H2,1-2H3
SMILES Code: C=C1CN(S(=O)(C2=CC=C(C)C=C2)=O)CCCN(CCCN(S(=O)(C3=CC=C(C)C=C3)=O)C1)CCC4=CC=CC=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 595.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Berger K, Pauwels E, Parkinson G, Landberg G, Le T, Demillo VG, Lumangtad LA, Jones DE, Islam MA, Olsen R, Kapri T, Intasiri A, Vermeire K, Rhost S, Bell TW. Reduction of Progranulin-Induced Breast Cancer Stem Cell Propagation by Sortilin-Targeting Cyclotriazadisulfonamide (CADA) Compounds. J Med Chem. 2021 Aug 24. doi: 10.1021/acs.jmedchem.1c00943. Epub ahead of print. PMID: 34428050.