WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H465614
CAS#: 2615911-12-9
Description: C3 DEPTOR Inhibitor is a Icaritin Derivative, and a Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment. Compound C3 exhibited better antimultiple myeloma activity with an IC50 of 1.09 μM for RPMI 8226 cells, induced RPMI 8226 apoptosis, and blocked the cell cycle in the S phase.
Hodoodo Cat#: H465614
Name: C3 DEPTOR Inhibitor
CAS#: 2615911-12-9
Chemical Formula: C24H16Cl2FNO4
Exact Mass: 471.04
Molecular Weight: 472.293
Elemental Analysis: C, 61.03; H, 3.41; Cl, 15.01; F, 4.02; N, 2.97; O, 13.55
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Synonym: C3 DEPTOR Inhibitor; C 3 DEPTOR Inhibitor; C-3 DEPTOR Inhibitor;
IUPAC/Chemical Name: 2-(3,4-dichlorophenyl)-9-(3-fluorobenzyl)-3-hydroxy-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazin-4-one
InChi Key: YHKREPOFPNSZAL-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H16Cl2FNO4/c25-18-6-4-14(9-19(18)26)23-22(30)21(29)16-5-7-20-17(24(16)32-23)11-28(12-31-20)10-13-2-1-3-15(27)8-13/h1-9,30H,10-12H2
SMILES Code: O=C1C(O)=C(C2=CC=C(Cl)C(Cl)=C2)OC3=C4CN(CC5=CC=CC(F)=C5)COC4=CC=C13
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 472.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Hou Y, Kuang W, Min W, Liu Z, Zhang F, Yuan K, Wang X, Sun C, Cheng H, Wang L, Xiao Y, Pu S, Xin GZ, Yang P. Design, Synthesis, and Biological Evaluation of Icaritin Derivatives as Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment. J Med Chem. 2021 Oct 13. doi: 10.1021/acs.jmedchem.1c00087. Epub ahead of print. PMID: 34644502.