ZL3138

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H465661

CAS#: unknown

Description: ZL3138 is a novel β-catenin/B-cell lymphoma 9 (BCL9) inhibitor, disrupting the β-catenin/BCL9 protein-protein interaction (PPI) with a Ki of 0.96 μM and without affecting the β-catenin/E-cadherin interaction in living cells, displaying good selectivity for β-catenin/BCL9 over β-catenin/E-cadherin PPIs.

Chemical Structure

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ZL3138
CAS# unknown
Instruction

Theoretical Analysis

Hodoodo Cat#: H465661
Name: ZL3138
CAS#: unknown
Chemical Formula: C37H53Cl2N5O3
Exact Mass: 685.35
Molecular Weight: 686.763
Elemental Analysis: C, 64.71; H, 7.78; Cl, 10.32; N, 10.20; O, 6.99

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ZL3138; ZL 3138; ZL-3138;

IUPAC/Chemical Name: (S)-2-((1-(3-(4-(tert-butyl)cyclohexyl)-4-(pyrrolidin-3-yloxy)benzoyl)piperidin-4-yl)oxy)-4-(piperazin-1-yl)benzonitrile dihydrochloride

InChi Key: BJLUZOOHVQRTRQ-BZWZXOHXSA-N

InChi Code: InChI=1S/C37H51N5O3.2ClH/c1-37(2,3)29-8-4-26(5-9-29)33-22-27(7-11-34(33)45-32-12-15-40-25-32)36(43)42-18-13-31(14-19-42)44-35-23-30(10-6-28(35)24-38)41-20-16-39-17-21-41;;/h6-7,10-11,22-23,26,29,31-32,39-40H,4-5,8-9,12-21,25H2,1-3H3;2*1H/t26?,29?,32-;;/m0../s1

SMILES Code: N#CC1=CC=C(N2CCNCC2)C=C1OC3CCN(C(C4=CC=C(O[C@@H]5CNCC5)C(C6CCC(C(C)(C)C)CC6)=C4)=O)CC3.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 686.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Li Z, Zhang M, Teuscher KB, Ji H. Discovery of 1-Benzoyl 4-Phenoxypiperidines as Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction. J Med Chem. 2021 Aug 12;64(15):11195-11218. doi: 10.1021/acs.jmedchem.1c00596. Epub 2021 Jul 16. PMID: 34270257.